Methylphenidate (MET) has a putative cognitive enhancer effect that has led adolescents and young adults to increase and indiscriminate its use aiming to ameliorate their productivity. However, the impacts of MET on addiction-related behaviors, emotional levels, and cognition are still not fully understood. To investigate the influence of chronic treatment with MET during adolescence on addiction-like behaviors, memory, and anxiety in adult mice. Thirty-day-old female mice received i.p. 10 mg/kg MET or Veh injections for 10 consecutive days. Forty days after the treatment (mice were 70-days-old), animals were submitted to the behavioral evaluation under the effects of MET, which included: MET-induced conditioned place preference (CPP), behavioral sensitization, and plus-maze discriminative avoidance task. Pre-exposure to MET during adolescence promoted an early expression of CPP and also facilitated the development of MET-induced behavioral sensitization during adulthood. These addictive-like behaviors were accompanied by anxiogenic effects of MET but not by any memory-enhancing effect. We demonstrated that exposure to MET during adolescence can increase the vulnerability to addiction-like behaviors and anxiety during adulthood. Our results reinforce the necessity of a more efficient system to control MET indiscriminate use, thus avoiding its potential tardive addictive effects.

哌甲酯 (MET) 具有公认的认知增强作用，导致青少年和年轻人增加和不分青红皂白地使用它，旨在提高他们的生产力。然而，MET对成瘾相关行为、情绪水平和认知的影响仍未完全了解。研究青春期用 MET 长期治疗对成年小鼠成瘾样行为、记忆和焦虑的影响。30 天大的雌性小鼠连续 10 天接受 ip 10 mg/kg MET 或 Veh 注射。治疗后 40 天（小鼠 70 天大），对动物进行 MET 影响下的行为评估，包括：MET 诱导的条件性位置偏好 (CPP)、行为敏化和十字迷宫区分回避任务。青春期预暴露于 MET 促进了 CPP 的早期表达，也促进了成年期 MET 诱导的行为敏化的发展。这些类似上瘾的行为伴随着 MET 的焦虑作用，但没有任何记忆增强作用。我们证明，在青春期接触 MET 会增加成年期对类似成瘾行为和焦虑的脆弱性。我们的结果强调了需要一个更有效的系统来控制 MET 的滥用，从而避免其潜在的迟发成瘾效应。我们证明，在青春期接触 MET 会增加成年期对类似成瘾行为和焦虑的脆弱性。我们的结果强调了需要一个更有效的系统来控制 MET 的滥用，从而避免其潜在的迟发成瘾效应。我们证明，在青春期接触 MET 会增加成年期对类似成瘾行为和焦虑的脆弱性。我们的结果强调了需要一个更有效的系统来控制 MET 的滥用，从而避免其潜在的迟发成瘾效应。