The zirconia implants have a wide range of clinical applications, however, the biological inertness and lack of osteoinductive properties limit these applications. Strontium possesses superior biocompatibility and excellent osteogenic properties. To take advantage of these, the strontium titanate-coated zirconia implants were prepared in this study by sandblasting, acid etching, and magnetron sputtering, followed by the analysis of the biological behavior. Briefly, the zirconia sheets were polished and subjected to sandblasting and acid etching. Subsequently, a nano‑strontium titanate coating was developed on the sheets by magnetron sputtering. The specimens were characterized by scanning electron microscopy (SEM), water contact angle measurement (WCA) and EDS mapping, which confirmed the physical alternation and successful deposition of the strontium titanate coating. The in vitro experiments indicated that the majority of the filopodia and actin fibers of the MC3T3-E1 cells on SA-ZrO₂/Sr possessed an optimal osteogenic property to promote the osteogenic differentiation. Moreover, the RT-PCR results revealed that SA-ZrO₂/Sr significantly up-regulated the gene expression of Runx2, COL-1, ALP, OPG, OPN and OCN. Further, the in vivo evaluation confirmed that the SA-ZrO₂/Sr implants promoted the bone-implant osseointegration to the greatest extent as compared to SA-ZrO₂ and ZrO₂ implant. Overall, the SA-ZrO₂/Sr system was confirmed to be a promising implant, thus, providing new pathways for an effective implant design.

氧化锆植入物具有广泛的临床应用，然而，生物惰性和骨诱导特性的缺乏限制了这些应用。锶具有优异的生物相容性和优异的成骨特性。为了利用这些优势，本研究通过喷砂、酸蚀刻和磁控溅射制备钛酸锶涂层氧化锆植入物，然后对其生物学行为进行分析。简而言之，将氧化锆片抛光并进行喷砂和酸蚀刻。随后，通过磁控溅射在片材上开发了纳米钛酸锶涂层。通过扫描电子显微镜 (SEM)、水接触角测量 (WCA) 和 EDS 映射对样品进行表征，这证实了钛酸锶涂层的物理交替和成功沉积。体外实验表明，SA-ZrO 上的 MC3T3-E1 细胞的大部分丝状伪足和肌动蛋白纤维₂ /Sr 具有促进成骨分化的最佳成骨特性。此外，RT-PCR结果显示SA-ZrO ₂ /Sr显着上调Runx2、COL-1、ALP、OPG、OPN和OCN的基因表达。此外，在体内评价证实，SA-的ZrO ₂相比，SA-的ZrO / SR植入物促进骨-植入物的骨整合，以最大程度地₂和ZrO ₂的植入物。总的来说，SA-ZrO ₂ /Sr 系统被证实是一种很有前途的植入物，因此为有效的植入物设计提供了新的途径。