Age-related cataract (ARC) is a primary cause of visual blindness worldwide. Lens epithelial cell (LEC) apoptosis, in which Fas plays an essential role, is a vital cytological basis for cataractogenesis. However, the regulatory mechanism of Fas-dependent LEC apoptosis is not well understood. This study aimed to investigate whether MicroRNA (miRNA)-124 can regulate LEC apoptosis by targeting polypyrimidine tract-binding protein (PTB) and thereby affecting Fas alternative splicing in ARC.

中文翻译：

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MicroRNA-124通过靶向年龄相关性白内障中的聚嘧啶束结合蛋白影响Fas选择性剪接来调节晶状体上皮细胞凋亡

年龄相关性白内障 (ARC) 是全球视盲的主要原因。晶状体上皮细胞 (LEC) 凋亡，其中 Fas 起重要作用，是白内障发生的重要细胞学基础。然而，Fas 依赖性 LEC 凋亡的调控机制尚不清楚。本研究旨在探讨 MicroRNA (miRNA)-124 是否可以通过靶向多嘧啶束结合蛋白 (PTB) 来调节 LEC 细胞凋亡，从而影响 ARC 中的 Fas 可变剪接。