当前位置: X-MOL 学术J. Environ. Health Sci. Eng. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Data validation of non- invasive carboxyhemoglobin measurement in recipient blood using numerical modeling data: a case of Himalayan regions’ households of Nepal
Journal of Environmental Health Science and Engineering ( IF 3.4 ) Pub Date : 2021-05-19 , DOI: 10.1007/s40201-020-00574-w
Indira Parajuli 1 , Dongwoo Jang 1
Affiliation  

Carbon monoxide decreases the oxygen carrying capacity of blood. As a result, it reduces the supply of oxygen into body cells and tissues including vital organs. It is poisonous during pregnancy as it leads to high risk for the mother and foetus. It causes the developmental disorders, cerebral anoxic lesions and even death of foetus. The major aim of this study is to validate the non- invasive % COHb monitored data with modelled data. IAQ instruments are administered to monitor CO concentraction and % COHb level in recipient’s blood. Thus, the level of % COHb in blood is approximated using numerical modeling to validate the monitored data with modeled data. Twenty four hours average CO concentration with TCS house is found 8.65 ± 7.77 ppm, 7.39 ± 5.62 ppm, 6.69 ± 7.16 ppm, 4.76 ± 7.19 ppm, 4.48 ± 6.10 ppm in the order of case II > case I > case V > case III > case IV, respectively. Twenty four hours average CO concentration with ICS house is found 3.54 ± 4.41 ppm, 2.41 ± 3.93 ppm, 2.30 ± 2.24 ppm, 1.70 ± 2.93 ppm and 1.51 ± 1.24 ppm in the order of case I > case V > case II > case IV > case III respectively. The average CO concentration in breath by cook is found 3.75 (3.75 ± 2.35)ppm in ICS using house and 5.36 (5.36 ± 4.54)ppm in TCS using house with minimum 0.60 ppm and maximum 31.34 ppm. The CO exposure is found more than 13 h a day for TCS using house and 9 h a day for ICS using house. The average cook_CO exposure is found 5.36 (5.36 ± 4.54)ppm and 3.75 (3.75 ± 2.35)ppm in sampled house using TCS and ICS respectively. The average percentage COHb in sampled house using TCS and ICS is found 4.31 (4.3 ± 5.35) % and 3.72 (3.72 ± 2.67) % respectively. The correlation between numerical modelling of COHb with non- invasive COHb measurement is found significant i.e. P value <0.00001 establishing r2 value 0.95 and 0.97 for ICS and TCS using house respectively.



中文翻译:

使用数值模拟数据对受体血液中无创碳氧血红蛋白测量的数据验证:以尼泊尔喜马拉雅地区家庭为例

一氧化碳会降低血液的携氧能力。结果,它减少了向包括重要器官在内的身体细胞和组织的氧气供应。它在怀孕期间有毒,因为它会对母亲和胎儿造成高风险。它会导致胎儿发育障碍、脑缺氧性病变甚至死亡。本研究的主要目的是使用建模数据验证无创 % COHb 监测数据。使用 IAQ 仪器来监测接受者血液中的 CO 浓度和 % COHb 水平。因此,血液中 % COHb 的水平使用数值建模来近似,以使用建模数据验证监测数据。发现 TCS 房屋的 24 小时平均 CO 浓度为 8.65 ± 7.77 ppm、7.39 ± 5.62 ppm、6.69 ± 7.16 ppm、4.76 ± 7.19 ppm、4.48 ± 6.10 ppm,顺序为案例 II > 案例 I > 案例 V > 案例 III > 案例 IV。发现 ICS 房屋的 24 小时平均 CO 浓度为 3.54 ± 4.41 ppm、2.41 ± 3.93 ppm、2.30 ± 2.24 ppm、1.70 ± 2.93 ppm 和 1.51 ± 1.24 ppm,顺序为案例 I > 案例 V > 案例 II > 案例 IV > 案例三。使用房屋的 ICS 中发现厨师呼吸中的平均 CO 浓度为 3.75 (3.75 ± 2.35)ppm,使用房屋的 TCS 中为 5.36 (5.36 ± 4.54)ppm,最低为 0.60 ppm,最高为 31.34 ppm。发现使用房屋的 TCS 暴露时间超过 13 公顷,使用房屋的 ICS 暴露时间超过 9 公顷。在使用 TCS 和 ICS 的采样房屋中,平均 cook_CO 暴露量分别为 5.36 (5.36 ± 4.54) ppm 和 3.75 (3.75 ± 2.35) ppm。使用 TCS 和 ICS 在抽样房屋中的平均 COHb 百分比分别为 4.31 (4.3 ± 5.35) % 和 3.72 (3.72 ± 2.67) %。P值 <0.00001 分别确定 ICS 和 TCS 使用 house 的 r 2值 0.95 和 0.97。

更新日期:2021-05-19
down
wechat
bug