N-methyl-D-aspartate (NMDA) receptor activation requires the binding of a co-agonist on the glycine-binding site. D-serine is the main endogenous co-agonist of NMDA receptors, and its availability significantly depends on the activity of the metabolic enzyme D-amino acid oxidase (DAAO). Inhibition of DAAO increases the brain levels of D-serine and modulates a variety of physiological functions, including cognitive behavior.

中文翻译：

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D-氨基酸氧化酶依赖性增强海马射击活动和被动回避学习的证据

N-甲基-D-天冬氨酸（NMDA）受体激活需要在甘氨酸结合位点上结合助激动剂。D-丝氨酸是NMDA受体的主要内源性协同激动剂，其可用性在很大程度上取决于代谢酶D-氨基酸氧化酶（DAAO）的活性。抑制DAAO可增加D-丝氨酸的大脑水平，并调节多种生理功能，包括认知行为。