Anhedonia, the loss of pleasure in previously rewarding activities, is a prominent feature of major depressive disorder and often resistant to first-line antidepressant treatment. A paucity of translatable cross-species tasks to assess subdomains of anhedonia, including reward learning, presents a major obstacle to the development of effective therapeutics. One assay of reward learning characterized by orderly behavioral and pharmacological findings in both humans and rats is the probabilistic reward task. In this computerized task, subjects make discriminations across numerous trials in which correct responses to one alternative are rewarded more often (rich) than correct responses to the other (lean). Healthy control subjects reliably develop a response bias to the rich alternative. However, participants with major depressive disorder as well as rats exposed to chronic stress typically exhibit a blunted response bias.

中文翻译：

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Mar猴奖励响应的翻译评估

快感缺乏症（Anhedonia）是先前抑郁症患者的一项享乐活动，它是主要抑郁症的突出特征，通常对一线抗抑郁药耐药。缺乏可评估的跨物种任务以评估快感缺乏症的亚域，包括奖励学习，这是开发有效疗法的主要障碍。一种在人和大鼠中以有序的行为和药理学发现为特征的奖励学习的方法是概率奖励任务。在这项计算机化任务中，受试者在众多试验中做出区分，在这些试验中，对一种选择的正确回答比对另一种选择的正确回答（瘦）得到的奖励更多（丰富）。健康对照组的受试者可靠地对丰富的替代品产生了反应偏差。然而，