Ketamine’s potent and rapid antidepressant properties have shown great promise to treat severe forms of major depressive disorder (MDD). A recently hypothesized antidepressant mechanism of action of ketamine is the inhibition of N-methyl-D-aspartate receptor–dependent bursting activity of the habenula (Hb), a small brain structure that modulates reward and affective states.

中文翻译：

---

Habenula连通性和静脉氯胺酮在抗抑郁药的治疗中

氯胺酮的有效和快速的抗抑郁特性已显示出治疗严重形式的严重抑郁症（MDD）的巨大希望。最近推测的氯胺酮抗抑郁作用机制是抑制the核（Hb）的N-甲基-D-天冬氨酸受体依赖性爆发活性，后者是调节奖赏和情感状态的小脑结构。