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Integration of 1:1 orthology maps and updated datasets into Echinobase
Database: The Journal of Biological Databases and Curation ( IF 5.8 ) Pub Date : 2021-05-01 , DOI: 10.1093/database/baab030
Saoirse Foley 1, 2 , Carolyn Ku 1, 2 , Brad Arshinoff 3 , Vaneet Lotay 3 , Kamran Karimi 3 , Peter D Vize 3 , Veronica Hinman 1, 2
Affiliation  

Echinobase (https://echinobase.org) is a central online platform that generates, manages and hosts genomic data relevant to echinoderm research. While the resource primarily serves the echinoderm research community, the recent release of an excellent quality genome for the frequently studied purple sea urchin (Strongylocentrotus purpuratus genome, v5.0) has provided an opportunity to adapt to the needs of a broader research community across other model systems. To this end, establishing pipelines to identify orthologous genes between echinoderms and other species has become a priority in many contexts including nomenclature, linking to data in other model organisms, and in internal functionality where data gathered in one hosted species can be associated with genes in other hosted echinoderms. This paper describes the orthology pipelines currently employed by Echinobase and how orthology data are processed to yield 1:1 ortholog mappings between a variety of echinoderms and other model taxa. We also describe functions of interest that have recently been included on the resource, including an updated developmental time course for S.purpuratus, and additional tracks for genome browsing. These data enhancements will increase the accessibility of the resource to non-echinoderm researchers and simultaneously expand the data quality and quantity available to core Echinobase users. Database URL: https://echinobase.org

中文翻译:

将 1:1 直系图和更新的数据集集成到 Echinobase 中

Echinobase (https://echinobase.org) 是一个中央在线平台,用于生成、管理和托管与棘皮动物研究相关的基因组数据。虽然该资源主要服务于棘皮动物研究界,但最近发布了经常研究的紫海胆的优质基因组(Strongylocentrotus purpuratus 基因组,v5.0),为适应其他领域更广泛的研究界的需求提供了机会。模型系统。为此,建立管道来识别棘皮动物和其他物种之间的直系同源基因已成为许多情况下的优先事项,包括命名、与其他模式生物中的数据链接,以及在内部功能中,在一个寄主物种中收集的数据可以与其他物种中的基因相关联。其他寄生的棘皮动物。本文描述了 Echinobase 目前使用的直系同源管道,以及如何处理直系同源数据以在各种棘皮动物和其他模型分类群之间产生 1:1 直系同源映射。我们还描述了最近包含在资源中的感兴趣的功能,包括更新的 S.purpuratus 发育时间进程,以及基因组浏览的其他轨迹。这些数据增强功能将提高非棘皮动物研究人员对资源的可访问性,同时扩大 Echinobase 核心用户可用的数据质量和数量。数据库网址:https://echinobase.org
更新日期:2021-05-01
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