Colorectal cancer is the most common gastrointestinal carcinoma in western countries. Prognosis of metastatic colorectal cancer has improved in the last decades, but the disease continues to carry an adverse outcome in most cases. An improved understanding of molecular pathogenesis has provided incremental benefits in survival outcomes with the introduction of targeted therapies for specific sub-types and gives hope for further improvements.

中文翻译：

---

结肠直肠癌中的染色体 20q11.21 扩增。

结直肠癌是西方国家最常见的胃肠道癌。在过去的几十年里，转移性结直肠癌的预后有所改善，但在大多数情况下，这种疾病仍然会带来不利的结果。随着对特定亚型的靶向治疗的引入，对分子发病机制的更好理解为生存结果提供了增量益处，并为进一步改进带来了希望。