Human Leukocyte Antigen-G (HLA-G) prevents the activity of immune cells and is decreased in women with preeclampsia. We aimed to investigate the associations between circulating soluble HLA-G (sHLA-G) and 92 cardiovascular disease-related biomarkers from a previously published multiplex study in women with preeclampsia and controls. We found 15 markers significantly associated with circulating sHLA-G in univariate analyses. After multivariable adjusted regression, only proto-oncogene tyrosine-protein kinase Src (SRC) and vascular endothelial growth factor D were significantly associated with sHLA-G. Low SRC, previously observed in the circulation of preeclamptic women, may be regulated by low sHLA-G, and reflect decreased trophoblast differentiation and syncytical formation.

人类白细胞抗原-G (HLA-G) 可阻止免疫细胞的活性，并在患有先兆子痫的女性中降低。我们旨在调查循环可溶性 HLA-G (sHLA-G) 与 92 种心血管疾病相关生物标志物之间的关联，这些生物标志物来自先前发表的针对先兆子痫和对照女性的多重研究。我们在单变量分析中发现了 15 个与循环 sHLA-G 显着相关的标志物。经过多变量调整回归后，只有原癌基因酪氨酸蛋白激酶 Src (SRC) 和血管内皮生长因子 D 与 sHLA-G 显着相关。先前在先兆子痫妇女的循环中观察到的低 SRC 可能受低 sHLA-G 的调节，并反映滋养层分化和合胞体形成减少。