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Low free testosterone level as a predictor of cardiovascular events in Japanese men with coronary risk factors
The Aging Male ( IF 2.6 ) Pub Date : 2021-05-17 , DOI: 10.1080/13685538.2021.1920912
Yuki Kato 1 , Kazuyoshi Shigehara 1 , Takahiro Inaba 2 , Jiro Sakamoto 3 , Masashi Iijima 1 , Shohei Kawaguchi 1 , Kouji Izumi 1 , Yoshifumi Kadono 1 , Mikio Namiki 4 , Atsushi Mizokami 1
Affiliation  

Abstract

Aim: We investigated whether low plasma free testosterone (FT) levels could predict cardiovascular events (CVE) in Japanese men with coronary risk factors.

Methods: Male patients with classical coronary risk factors who had undergone serum FT testing were enrolled. New incidences of CVE were retrospectively investigated among all eligible participants based on their medical records.

Results: Overall, 466 male outpatients with coronary risk factors without a previous history of CVE were identified. Throughout the follow-up period (median = 92 months), 126 CVE occurred. The Kaplan–Meier survival analysis according to the tertiles of plasma FT levels revealed that patients with the lowest FT tertile (<6.5 pg/mL) had a higher likelihood of developing CVE than those with the highest tertile (>9.3 pg/mL) (p<.01). Multivariate analysis showed that increased frequency of CVE was observed with lower FT tertiles, independent of other coronary risk factors, with hazard ratios of 0.617 (95% CI, 0.389–0.976; p=.030) and 0.524 (95% CI, 0.309–0.887; p=.016) for the second and highest tertile relative to the lowest FT tertile, respectively.

Conclusion: Among Japanese men with coronary risk factors, a lower FT level was a predictor for the development of cardiovascular diseases independent of other coronary risk factors and age.



中文翻译:

低游离睾酮水平作为具有冠状动脉危险因素的日本男性心血管事件的预测因子

摘要

目的:我们研究了低血浆游离睾酮 (FT) 水平是否可以预测具有冠状动脉危险因素的日本男性的心血管事件 (CVE)。

方法:纳入接受血清 FT 检测的具有经典冠状动脉危险因素的男性患者。根据所有符合条件的参与者的医疗记录,对 CVE 的新发病率进行了回顾性调查。

结果:总体而言,确定了 466 名具有冠状动脉危险因素且既往无 CVE 病史的男性门诊患者。在整个随访期间(中位数 = 92 个月),发生了 126 例 CVE。根据血浆 FT 水平的三分位数进行的 Kaplan-Meier 生存分析显示,FT 三分位数最低 (<6.5 pg/mL) 的患者发生 CVE 的可能性高于三分位数最高 (>9.3 pg/mL) 的患者。p <.01)。多变量分析显示,在 FT 三分位数较低的情况下观察到 CVE 的频率增加,与其他冠状动脉危险因素无关,风险比为 0.617(95% CI,0.389–0.976;p =.030)和 0.524(95% CI,0.309– 0.887; p=.016) 分别表示相对于最低 FT 三分位数的第二和最高三分位数。

结论:在具有冠状动脉危险因素的日本男性中,较低的 FT 水平是心血管疾病发展的预测因素,与其他冠状动脉危险因素和年龄无关。

更新日期:2021-05-18
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