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Tissue-Specific Distribution of Legacy and Novel Per- and Polyfluoroalkyl Substances in Juvenile Seabirds
Environmental Science & Technology Letters ( IF 10.9 ) Pub Date : 2021-05-17 , DOI: 10.1021/acs.estlett.1c00222
Anna R Robuck 1 , James P McCord 2 , Mark J Strynar 2 , Mark G Cantwell 3 , David N Wiley 4 , Rainer Lohmann 1
Affiliation  

Of the thousands of per- and polyfluoroalkyl substances (PFAS) in the environment, few have been investigated in detail. In this study, we analyzed 36 legacy and emerging PFAS in multiple seabird tissues collected from individuals from Massachusetts Bay, Narragansett Bay, and the Cape Fear River Estuary. PFOS was the dominant compound across multiple tissues, while long-chain perfluorinated carboxylic acids (PFCAs) dominated in brain (mean = 44% of total concentrations). Emerging perfluoroalkyl ether acids (PFEAs)—Nafion byproduct-2 and PFO5DoDA—were detected in greater than 90% of tissues in birds obtained from a nesting region downstream from a major fluorochemical production site. Compound ratios, relative body burden calculations, and electrostatic surface potential calculations were used to describe partitioning behavior of PFEAs in different tissues. Novel PFEAs preferentially partition into blood compared to liver and were documented in brain for the first time. PFO5DoDA showed a reduced preference for brain compared to PFCAs and Nafion BP2. These results suggest future monitoring efforts and toxicological studies should focus on novel PFAS and long-chain PFCAs in multiple tissues beyond liver and blood, while exploring the unique binding mechanisms driving uptake of multi-ether PFEAs.

中文翻译:

幼年海鸟中传统和新型全氟和多氟烷基物质的组织特异性分布

在环境中数以千计的全氟和多氟烷基物质 (PFAS) 中,很少有人进行了详细研究。在这项研究中,我们分析了从马萨诸塞湾、纳拉甘西特湾和开普菲尔河河口的个体采集的多种海鸟组织中的 36 种遗留和新兴 PFAS。PFOS 是多种组织中的主要化合物,而长链全氟羧酸 (PFCA) 在大脑中占主导地位(平均值 = 总浓度的 44%)。新出现的全氟烷基醚酸 (PFEA)——Nafion 副产品 2 和 PFO5DoDA——在从主要氟化物生产地点下游的筑巢区获得的鸟类组织中超过 90% 的组织中检测到。复合比率,相对身体负担计算,和静电表面电位计算用于描述PFEA在不同组织中的分配行为。与肝脏相比,新型 PFEA 优先分配到血液中,并首次在大脑中记录。与 PFCA 和 Nafion BP2 相比,PFO5DoDA 对大脑的偏好降低。这些结果表明,未来的监测工作和毒理学研究应侧重于肝脏和血液以外的多个组织中的新型 PFAS 和长链 PFCA,同时探索推动多醚 PFEA 摄取的独特结合机制。
更新日期:2021-06-08
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