Abstract

The aim of the study was to analyze the association of a complex of anthropogenetic and environmental factors with the subcutaneous and visceral fat indices measured by local configurations of bioimpedance analysis in ethnic Altaians. This study involved 110 relatively healthy men (62) and women (48), representatives of the indigenous peoples of Altai, aged from 17 to 35 years. The study program included anthropometric examination, determination of body composition using bioimpedance (ABC-02 Medass analyzer), measurement of local impedances in the abdominal region, and identification of genotypes by polymorphic systems of uncoupling protein genes UCP1–3. Sexual dimorphism was shown for most of the studied morphological and functional traits. Subcutaneous and visceral fat indices were found to be highly correlated with the index of central obesity and body fat percentage. Endogenous traits, sex, age, and the number of “thrifty” alleles of the genes of uncoupling proteins 1–3 did not have a significant effect on the subcutaneous and visceral fat indices in the examined group of young people (17–35 years old). Informative feature selection using random forests and the Boruta algorithm revealed that the leading predictors associated with abdominal topography of fat deposition in the examined group are WHtR (Waist-to-height ratio) and BFP (body fat percentage).

中文翻译：

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阿尔泰共和国成年人口的皮下和内脏脂肪指数及其与内源性和外源性因素的复合关系

摘要

这项研究的目的是分析人类遗传学和环境因素的复杂性与皮下和内脏脂肪指数的关系，该指标通过生物阻抗分析的局部结构在阿尔泰族裔中测量。这项研究涉及110名相对健康的男性（62岁）和女性（48岁），这是阿尔泰土著人民的代表，年龄在17至35岁之间。该研究计划包括人体测量学，使用生物阻抗（ABC-02 Medass分析仪）确定身体成分，测量腹部区域的局部阻抗以及通过解偶联蛋白基因UCP1-3的多态系统鉴定基因型。。大多数研究的形态和功能性状都表现出性二态性。发现皮下和内脏脂肪指数与中型肥胖指数和体脂百分比高度相关。在所检查的年轻人组（17-35岁）中，内在性状，性别，年龄和解偶联蛋白1-3的基因的“节俭”等位基因数目对皮下和内脏脂肪指数没有显着影响）。使用随机森林和Boruta算法进行的情报性特征选择显示，与受试组腹部脂肪沉积地形有关的主要预测因素是WHtR（腰围身高比）和BFP（体脂百分比）。