Immunological memory is a hallmark of adaptive immunity that confers long-lasting protection from reinfections. Memory CD8⁺ T cells provide protection by actively scanning for their cognate antigen and migrating into inflamed tissues. Trafficking patterns of CD8⁺ T cells are also a major determinant of cell fate outcomes during differentiation into effector and memory cell states. CD8⁺ T-cell trafficking must therefore be dynamically and tightly regulated to ensure that CD8⁺ T cells arrive at the correct locations and differentiate to acquire appropriate effector functions. This review aims to discuss the importance of CD8⁺ T-cell trafficking patterns in regulating effector and memory differentiation, maintenance, and reactivation.

中文翻译：

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运动性很重要：CD8+ T 细胞运输如何影响效应细胞和记忆细胞分化

免疫记忆是适应性免疫的标志，可提供持久的保护，防止再次感染。记忆 CD8 ⁺ T 细胞通过主动扫描其同源抗原并迁移到发炎组织中来提供保护。CD8 ⁺ T 细胞的运输模式也是分化为效应细胞和记忆细胞状态期间细胞命运结果的主要决定因素。因此， CD8 ⁺ T 细胞运输必须受到动态和严格的调控，以确保 CD8 ⁺ T 细胞到达正确的位置并分化以获得适当的效应功能。^{本综述旨在讨论 CD8 +} T 细胞运输模式在调节效应器和记忆分化、维持和重新激活中的重要性。