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Diversity in immunogenomics: the value and the challenge
Nature Methods ( IF 48.0 ) Pub Date : 2021-05-17 , DOI: 10.1038/s41592-021-01169-5
Kerui Peng, Yana Safonova, Mikhail Shugay, Alice B. Popejoy, Oscar L. Rodriguez, Felix Breden, Petter Brodin, Amanda M. Burkhardt, Carlos Bustamante, Van-Mai Cao-Lormeau, Martin M. Corcoran, Darragh Duffy, Macarena Fuentes-Guajardo, Ricardo Fujita, Victor Greiff, Vanessa D. Jönsson, Xiao Liu, Lluis Quintana-Murci, Maura Rossetti, Jianming Xie, Gur Yaari, Wei Zhang, Malak S. Abedalthagafi, Khalid O. Adekoya, Rahaman A. Ahmed, Wei-Chiao Chang, Clive Gray, Yusuke Nakamura, William D. Lees, Purvesh Khatri, Houda Alachkar, Cathrine Scheepers, Corey T. Watson, Gunilla B. Karlsson Hedestam, Serghei Mangul

Immunogenomics studies have been largely limited to individuals of European ancestry, restricting the ability to identify variation in human adaptive immune responses across populations. Inclusion of a greater diversity of individuals in immunogenomics studies will substantially enhance our understanding of human immunology.

中文翻译:

免疫基因组学的多样性:价值与挑战

免疫基因组学研究在很大程度上仅限于欧洲血统的个体,限制了识别人群间人类适应性免疫反应变异的能力。在免疫基因组学研究中纳入更多样化的个体将大大增强我们对人类免疫学的理解。
更新日期:2021-05-18
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