ABSTRACT

Background

We aimed to determine the optimal range of discharge serum magnesium in hospitalized patients by evaluating one-year mortality risk according to discharge serum magnesium.

Methods

This was a single-center cohort study of hospitalized adult patients who survived until hospital discharge. We classified discharge serum magnesium, defined as the last serum magnesium within 48 hours of hospital discharge, into ≤1.6, 1.7–1.8, 1.9–2.0, 2.1–2.2, and ≥2.3 mg/dL. We assessed one-year mortality risk after hospital discharge based on discharge serum magnesium, using discharge magnesium of 2.1–2.2 mg/dL as the reference group.

Results

Of 39,193 eligible patients, 8%, 23%, 34%, 23%, and 12% had a serum magnesium of ≤1.6, 1.7–1.8, 1.9–2.0, 2.1–2.2, and ≥2.3 mg/dL, respectively, at hospital discharge. After the adjustment for several confounders, discharge serum magnesium of ≤1.6, 1.7–1.8, and ≥2.3 mg/dL were associated with higher one-year mortality with hazard ratio of 1.35 (95% CI 1.21–1.50), 1.14 (95% CI 1.06–1.24), and 1.17 (95% CI 1.07–1.28), respectively, compared to discharge serum magnesium of 2.1–2.2 mg/dL. There was no significant difference in one-year mortality between patients with discharge serum magnesium of 1.9–2.0 and 2.1–2.2 mg/dL.

Conclusion

The optimal range of serum magnesium at discharge was 1.9–2.2 mg/dL. Both hypomagnesemia and hypermagnesemia at discharge were associated with higher one-year mortality.

中文翻译：

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出院时血清镁水平和一年死亡率的影响

摘要

背景

我们旨在通过根据出院血清镁评估一年死亡风险来确定住院患者出院血清镁的最佳范围。

方法

这是一项针对存活到出院的住院成年患者的单中心队列研究。我们将出院血清镁（定义为出院 48 小时内的最后一次血清镁）分为≤1.6、1.7–1.8、1.9–2.0、2.1–2.2 和≥2.3 mg/dL。我们根据出院血清镁评估出院后一年的死亡风险，使用出院镁 2.1-2.2 mg/dL 作为参考组。

结果

在 39,193 名符合条件的患者中，8%、23%、34%、23% 和 12% 的血清镁分别为 ≤1.6、1.7–1.8、1.9–2.0、2.1–2.2 和 ≥2.3 mg/dL，在出院。在调整几个混杂因素后，出院血清镁≤1.6、1.7–1.8 和 ≥2.3 mg/dL 与较高的一年死亡率相关，风险比为 1.35 (95% CI 1.21–1.50)、1.14 (95% CI 1.06–1.24) 和 1.17 (95% CI 1.07–1.28)，而排出血清镁为 2.1–2.2 mg/dL。出院血清镁为 1.9-2.0 和 2.1-2.2 mg/dL 的患者的一年死亡率没有显着差异。

结论

出院时血清镁的最佳范围为 1.9-2.2 mg/dL。出院时的低镁血症和高镁血症均与较高的一年死亡率相关。