Allergic asthma is a common inflammatory lung disease and a major health problem worldwide. Mast cells (MCs) play a key role in the early-stage pathophysiology of allergic asthma. Substance P (SP) functions in neurogenic inflammation by activating MCs, and therefore, it may to participate in the occurrence and development of asthma.

中文翻译：

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P物质诱导的小鼠肺部炎症是肥大细胞依赖性的

过敏性哮喘是一种常见的炎症性肺病，是世界范围内的主要健康问题。肥大细胞（MCs）在过敏性哮喘的早期病理生理学中起关键作用。P物质(SP)通过激活MCs在神经源性炎症中发挥作用，因此可能参与哮喘的发生和发展。