Introduction: While there exists considerable evidence for efficacy of sublingual immunotherapy (SLIT), its impact on the improvement of nasal signs in allergic rhinitis (AR) patients remains quite unclear. In this study, the endoscopic examination and the modified Lund-Kennedy (MLK) scoring system were performed to describe and evaluate the therapeutic effect of SLIT. Methods: A total of 105 patients with AR induced by house dust mites were enrolled and treated with standardized Dermatophagoides farinae (D. farinae) drops for 1 year. The total nasal symptoms score (TNSS), total medication score (TMS), visual analog scale (VAS), and MLK scores were assessed at baseline and 6 and 12 months. The MLK score was also compared for its correlation with TNSS, TMS, and VAS. Results: The TNSS, TMS, and VAS scores statistically decreased after SLIT compared to baseline (all p #x3c; 0.05). After 12 months of treatment, the rates of well-controlled, partial controlled, and uncontrolled AR patients were 42, 49.5, and 8.5%, respectively. The nasal endoscopy findings showed significant improvement in nasal signs, which mainly included color change of turbinate mucosa, reduction of nasal secretions, and improvement of nasal edema. A significant decrease was observed in MLK scores, and there was a positive correlation between MLK and VAS scores. Conclusions: In addition to commonly utilized subjective assessments (TMS, TNSS, and VAS), our results of endoscopic examination and the MLK scores consistently confirmed that SLIT is an effective therapeutic modality for AR patients. The MLK scores might be considered as an auxiliary tool to evaluate efficacy of SLIT in clinical practice and outcomes research.
Int Arch Allergy Immunol

中文翻译：

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鼻内窥镜在过敏性鼻炎和屋尘螨舌下免疫治疗中的作用

简介：虽然有大量证据表明舌下免疫疗法 (SLIT) 的有效性，但其对过敏性鼻炎 (AR) 患者鼻部症状改善的影响仍不清楚。本研究通过内镜检查和改良的 Lund-Kennedy (MLK​​) 评分系统来描述和评估 SLIT 的治疗效果。方法：共纳入 105 例房尘螨诱发的 AR 患者，采用标准化粉尘螨（ D. farinae) 下降 1 年。在基线和 6 个月和 12 个月时评估总鼻症状评分 (TNSS)、总药物评分 (TMS)、视觉模拟量表 (VAS) 和 MLK 评分。还比较了 MLK 评分与 TNSS、TMS 和 VAS 的相关性。结果：与基线相比，SLIT 后 TNSS、TMS 和 VAS 评分在统计学上有所降低（所有p#x3c; 0.05）。治疗 12 个月后，AR 患者控制良好、部分控制和未控制的比率分别为 42%、49.5% 和 8.5%。鼻内镜检查结果显示鼻体征明显改善，主要包括鼻甲黏膜颜色改变、鼻腔分泌物减少、鼻水肿改善。MLK 评分显着下降，MLK 与 VAS 评分呈正相关。结论：除了常用的主观评估（TMS、TNSS 和 VAS）外，我们的内窥镜检查结果和 MLK 评分一致证实 SLIT 是 AR 患者的有效治疗方式。MLK 评分可被视为评估 SLIT 在临床实践和结果研究中的功效的辅助工具。
Int Arch 过敏免疫