Currently 12 human polyomaviruses (HPyVs) have been identified, 6 of which have been associated with human diseases, including cancer. The discovery of the Merkel cell polyomavirus and its role in the etiopathogenesis in the majority of Merkel cell carcinomas has drawn significant attention, also to other novel HPyVs. In 2010, HPyV6 and HPyV7 were identified in healthy skin swabs. Ever since it has been speculated that they might contribute to the etiopathogenesis of skin and non-cutaneous human cancers. Here we comprehensively reviewed and summarized the current evidence potentially indicating an involvement of HPyV6 and HPyV7 in the etiopathogenesis of neoplastic human diseases. The seroprevalence of both HPyV6 and 7 is high in a normal population and increases with age. In skin cancer tissues, HPyV6- DNA was far more often prevalent than HPyV7 in contrast to cancers of other anatomic sites, in which HPyV7 DNA was more frequently detected. It is remarkable to find that the detection rate of HPyV6-DNA in tissues of skin malignancies is higher than HPyV7-DNA and may indicate a role of HPyV6 in the etiopathogenesis of the respected skin cancers. However, the sheer presence of viral DNA is not enough to prove a role in the etiopathogenesis of these cancers.

中文翻译：

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人类多瘤病毒 6 和 7 在人类癌症中的新作用

目前已鉴定出 12 种人类多瘤病毒 (HPyV)，其中 6 种与包括癌症在内的人类疾病有关。Merkel 细胞多瘤病毒的发现及其在大多数 Merkel 细胞癌发病机制中的作用引起了人们的极大关注，其他新型 HPyV 也是如此。2010 年，在健康的皮肤拭子中发现了 HPyV6 和 HPyV7。自从有人推测它们可能有助于皮肤和非皮肤人类癌症的发病机制。在这里，我们全面回顾和总结了当前的证据，这些证据可能表明 HPyV6 和 HPyV7 参与了人类肿瘤疾病的发病机制。HPyV6 和 7 的血清阳性率在正常人群中都很高，并且随着年龄的增长而增加。在皮肤癌组织中，与其他解剖部位的癌症相比，HPyV6-DNA 比 HPyV7 更常见，在这些癌症中更频繁地检测到 HPyV7 DNA。值得注意的是，皮肤恶性肿瘤组织中HPyV6-DNA的检出率高于HPyV7-DNA，这可能表明HPyV6在相关皮肤癌发病机制中的作用。然而，病毒 DNA 的纯粹存在不足以证明在这些癌症的发病机制中的作用。