Excellent outcomes have been reported following thyroidectomy for thyroid carcinoma in dogs, but outcomes for thyroid carcinomas with gross vascular invasion are poorly described. This study describes the clinical outcomes and complications in dogs with thyroid carcinomas with gross vascular invasion undergoing thyroidectomy. Medical records of dogs that underwent thyroidectomy between January 1st 2010 and December 31st 2019 were reviewed at 10 hospitals. Signalment, diagnostic data, primary and adjuvant treatments performed, and outcome were abstracted. Survival was calculated using Kaplan–Meier analysis. Multiple logistic regression was used to identify variables associated with disease-specific survival. Seventy-three dogs were included, of which 58 underwent unilateral thyroidectomy and 15 underwent bilateral thyroidectomy. Complications were reported in five dogs (three major, two minor; 6.8%) intraoperatively and 12 dogs (two major leading to death, 10 minor; 16.4%) postoperatively. Seven (9.6%) dogs developed locoregional recurrence at a median of 238 days postoperatively (range: 15–730 days). Distant metastasis was suspected or confirmed in nine dogs (12.3%) at a median of 375 days postoperatively (range: 50–890 days). Twenty-seven dogs (37%) received adjuvant therapy (chemotherapy: n = 21; radiotherapy: n = 6). Thirty-nine dogs were euthanized or died, with 20 deaths related to disease (n = 10) or of unknown cause (n = 10), 19 due to unrelated causes, and nine lost to follow-up. Median overall and disease-specific survival were 621 days and not reached respectively. One-year disease-specific survival rate was 82.5%. No variables were associated with disease-specific survival in our dataset. Surgery may be considered for loco-regional therapy in dogs with thyroid carcinoma with gross vascular invasion.

中文翻译：

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73 只甲状腺癌伴甲状腺切除术治疗大血管侵犯犬的预后和术后并发症

已经报道了犬甲状腺癌切除甲状腺后的良好结果，但对伴有大血管侵犯的甲状腺癌的结果描述甚少。本研究描述了患有甲状腺癌的犬接受甲状腺切除术的大血管侵犯的临床结果和并发症。在 10 家医院审查了 2010 年 1 月 1 日至 2019 年 12 月 31 日期间接受甲状腺切除术的狗的医疗记录。对信号、诊断数据、进行的主要和辅助治疗以及结果进行了抽象。使用 Kaplan-Meier 分析计算存活率。多元逻辑回归用于识别与疾病特异性生存相关的变量。包括 73 只狗，其中 58 只接受了单侧甲状腺切除术，15 只接受了双侧甲状腺切除术。5 只狗（3 只严重，2 只轻微；6.8%）术中和 12 只狗（2 只主要导致死亡，10 只轻微；16.4%）术后出现并发症。7 只 (9.6%) 犬在术后 238 天（范围：15-730 天）出现局部复发。9 只狗（12.3%）在术后 375 天（范围：50-890 天）的中位时间怀疑或确认远处转移。27 只狗 (37%) 接受了辅助治疗（化疗：n  = 21; 放疗：n  = 6)。39 只狗被安乐死或死亡，其中 20 只与疾病相关（n  = 10）或不明原因（n  = 10）死亡，19 只因无关原因死亡，9 只失访。中位总生存期和疾病特异性生存期分别为 621 天且未达到。一年疾病特异性生存率为82.5%。在我们的数据集中，没有变量与疾病特异性生存相关。对于患有甲状腺癌并伴有明显血管侵犯的犬，可以考虑手术进行局部治疗。