Background

The coronavirus disease 2019 pandemic has highlighted the importance of accurate capture of vaccine, and vaccine component, allergy. There remains a gap in the prevalence literature from the perspective of direct primary care provider (PCP) reporting at a population level.

Objective

To determine the prevalence of PCP-documented vaccine and polyethylene glycol (PEG) allergy using electronic medical record data from the Canadian Primary Care Sentinel Surveillance Network.

Methods

Retrospective cohort study using the Canadian Primary Care Sentinel Surveillance Network repository. Machine learning algorithms were applied to evaluate for vaccine allergy documentation, and Anatomic Therapeutic Chemical codes were used for PEG allergy or allergy to common injectable medications containing PEG (CIMCP).

Results

The prevalence of PCP-documented vaccine allergy in Canada was 0.037% (395/1,055,677) and of PEG allergy was 0.0009% (10/1,055,677). In total, 0.01% of patients had a documented allergy to either PEG or CIMCP (135/1,055,677). None of the patients with PEG allergy had a documented allergy to a CIMCP. Patients with vaccine allergy and PEG allergy were significantly more likely to have other atopic comorbidities, including asthma (P < .001 for both), eczema (P < .001 and P = .001, respectively), rhinitis (P = .002 and P < .001, respectively), and food allergy (P < .001 for both). Significantly higher rates of depression (P < .001 and P < .001, respectively) and anxiety (P = .003 and P < .001, respectively) were found in those with vaccine allergy, or PEG allergy, than those without vaccine allergy or PEG allergy.

Conclusion

This is the first study to estimate the prevalence of vaccine and PEG allergy in a national cohort that uses PCP documentation, revealing a low reported rate of vaccine allergy and PEG allergy.

中文翻译：

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加拿大初级保健提供者报告的疫苗和聚乙二醇过敏流行率

背景

2019 年冠状病毒病大流行凸显了准确捕获疫苗、疫苗成分、过敏的重要性。从人口水平的直接初级保健提供者 (PCP) 报告的角度来看，流行率文献中仍然存在差距。

客观的

使用来自加拿大初级保健哨兵监测网络的电子病历数据确定 PCP 记录的疫苗和聚乙二醇 (PEG) 过敏的流行率。

方法

使用加拿大初级保健哨兵监视网络存储库的回顾性队列研究。机器学习算法用于评估疫苗过敏文件，解剖治疗化学代码用于 PEG 过敏或对含有 PEG 的常见注射药物过敏 (CIMCP)。

结果

在加拿大，PCP 记录的疫苗过敏的患病率为 0.037% (395/1,055,677)，PEG 过敏的患病率为 0.0009% (10/1,055,677)。总共有 0.01% 的患者记录了对 PEG 或 CIMCP 过敏 (135/1,055,677)。PEG 过敏患者均未记录对 CIMCP 过敏。疫苗过敏和 PEG 过敏的患者明显更有可能患有其他特应性合并症，包括哮喘（两者P < .001）、湿疹（分别为P < .001 和P  = .001）、鼻炎（P  = .002 和P < .001）和食物过敏（两者P < .001）。显着更高的抑郁率（P < .001 和P< .001）和焦虑（分别为P  = .003 和P < .001）在疫苗过敏或 PEG 过敏的人群中比没有疫苗过敏或 PEG 过敏的人群更严重。

结论

这是第一项使用 PCP 文件估计全国队列中疫苗和 PEG 过敏流行率的研究，揭示了疫苗过敏和 PEG 过敏的报告率较低。