Cisplatin (CISP) is one of the most commonly used drug for treating various cancers and solid tumours, however, its usage has been heavy restricted due to its deleterious side effects including peripheral neuropathy. Therefore, this study describes the anti-hyperalgesia and anti-allodynia effects of Tiliacora triandra (TTE) in CISP induced peripheral neuropathy. Peripheral neuropathy was established in rats by intraperitoneal injection of 2.5 mg/kg of CISP once a week for 4 weeks and the rats were concurrently treated with TTE (250 and 500 mg/kg, po) daily for 5 weeks. After the treatment, thermal hyperalgesia, motor coordination (rotarod test), mechanical allodynia, acetic acid writhing and formalin tests were evaluated. The rats were sacrificed and blood samples were collected for estimation of haematological parameters. TTE significantly restored motor coordination deficits induced by CISP and TTE-treated rats showed marked improvement in thermal/chemical hyperalgesia and mechanical allodynia. Additionally, treatment with TTE also increased haematological parameters including haemoglobin, platelet count, WBC and RBC compared to CISP-treated group. These findings demonstrated that TTE effectively ameliorated CISP induced peripheral neuropathic pain in a cisplatin paradigm.

顺铂（CISP）是用于治疗各种癌症和实体瘤的最常用药物之一，但是由于其有害的副作用（包括周围神经病变），其使用受到了严格的限制。因此，本研究描述了tri虫的抗痛觉过敏和抗痛觉过敏作用（TTE）在CISP中引起周围神经病变。每周一次腹膜内注射2.5 mg / kg CISP，持续4周，从而在大鼠中建立周围神经病变，并每天同时用TTE（250和500 mg / kg，口服）治疗大鼠，持续5周。治疗后，对热痛觉过敏，运动协调（罗塔罗德测试），机械性异常性疼痛，乙酸扭体和福尔马林测试进行了评估。处死大鼠并收集血液样品以评估血液学参数。TTE显着恢复了CISP诱导的运动协调障碍，TTE治疗的大鼠在热/化学痛觉过敏和机械性异常性疼痛方面表现出明显的改善。此外，与CISP治疗组相比，TTE治疗还增加了血液学参数，包括血红蛋白，血小板计数，WBC和RBC。