Designing new types of drugs with preferred properties against cancer is a great issue for scientists dealing with synthesis and study of biological activity. Several organometallic compounds used in chemotherapy reveal side effects. Peptides from edible sources having no side effects may play a transport role in the delivery of anticancer metal ions into targeted tumor cells. For the last two decades, peptide-metal complexes have been considered as potential anticancer agents. In this work, oxovanadium complexes of peptides from Chickpea (Cicer arietinum L.) seeds’ protein hydrolysate were investigated. The albumin fraction of Chickpea seeds protein was hydrolyzed with a combination of enzymes papain, trypsin, and alcalase. The hydrolysate was combined with vanadyl ions and obtained oxovanadium complexes were studied by FTIR, SEM–EDX, and TG-DSC analyses, and cell inhibition activity against A549 cells was detected by MTT Assay. In a result, activity of the complexes (IC₅₀ = 14.39 µg/mL) increased 1.7-fold compared to the activity of inorganic salt of vanadium (IC₅₀ = 24.75 µg/mL) against A549 cells. The complexes (CPH-V) were fractionated through Sephadex G-15, and the second active fraction, named CPH-V G15-II was studied by nano-Q-TOF LC/MS. Nine peptides with a molecular mass range of 437–1864 Da were identified. Seven of them were theoretically considered as cell-penetrating peptides. These results could serve first steps for deeper fundamental research on food-derived peptide-vanadium complexes.

对于从事生物活性合成和研究的科学家来说，设计具有抗癌特性的新型药物是一个大问题。化疗中使用的几种有机金属化合物显示出副作用。来自可食用来源的无副作用的肽可能在将抗癌金属离子输送到靶向肿瘤细胞中发挥运输作用。在过去的二十年里，肽-金属复合物被认为是潜在的抗癌剂。在这项工作中，鹰嘴豆 ( Cicer arietinum)肽的氧钒配合物L.) 研究了种子的蛋白质水解物。鹰嘴豆种子蛋白的白蛋白部分用木瓜蛋白酶、胰蛋白酶和碱性蛋白酶的组合水解。水解产物与钒离子结合，得到的氧钒配合物通过 FTIR、SEM-EDX 和 TG-DSC 分析进行研究，并通过 MTT 分析检测对 A549 细胞的细胞抑制活性。在其结果是，复合物的活性（IC ₅₀  = 14.39微克/毫升）1.7增加倍相比钒的无机盐的活性（IC ₅₀ = 24.75 µg/mL）针对 A549 细胞。复合物 (CPH-V) 通过 Sephadex G-15 进行分级分离，并通过 nano-Q-TOF LC/MS 研究名为 CPH-V G15-II 的第二个活性部分。鉴定了 9 种分子量范围为 437–1864 Da 的肽。其中七种在理论上被认为是细胞穿透肽。这些结果可以作为更深入的食品衍生肽-钒配合物基础研究的第一步。