Na⁺, Cl⁻ and K⁺ are the most abundant electrolytes present in biological fluids that are essential to the regulation of pH homeostasis, membrane potential and cell volume in living organisms. Herein, we report synthetic crown ether-thiourea conjugates as a cation/anion symporter, which can transport both Na⁺ and Cl⁻ across lipid bilayers with relatively high transport activity. Surprisingly, the ion transport activities were diminished when high concentrations of K⁺ ions were present outside the vesicles. This unusual behavior resulted from the strong affinity of the transporters for K⁺ ions, which led to predominant partitioning of the transporters as the K⁺ complexes in the aqueous phase preventing the transporter incorporation into the membrane. Synthetic membrane transporters with Na⁺, Cl⁻ and K⁺ transport capabilities may have potential biological and medicinal applications.

的Na ⁺，氯^-和K ⁺是最丰富的电解质存在于对pH稳态，膜电位和在活生物细胞体积的调节所必需的生物流体。在本文中，我们报道了合成的冠醚-硫脲缀合物作为阳离子/阴离子转运体，其可输送两者的Na ⁺和Cl ^-具有相对高的转运活性跨脂质双层。出人意料的是，当囊泡外部存在高浓度的K ⁺离子时，离子的转运活性就会降低。这种异常的行为是由于转运蛋白对K ⁺的强烈亲和力造成的。离子，这导致转运蛋白的主要分配，因为水相中的K ⁺络合物阻止了转运蛋白掺入膜中。与钠合成膜转运蛋白⁺，氯^-和K ⁺运输能力可能有潜在的生物和医药应用。