Background. The prevalence and incidence rate of epilepsy were found to be higher in low- and middle-income countries. Uncontrolled epilepsy has a high risk of disability, stigma, discrimination, human rights violations, and premature death. The available studies of controlled seizure in Ethiopia have showed inconsistent results which calls for systematic review and meta-analysis. Therefore, this review intended to show the pooled prevalence of controlled seizure among people with epilepsy receiving antiepileptic drugs at outpatient department. Methods. A systematic literature search was conducted using PubMed/Medline, Science Direct, PsycINFO, Hinnarri databases, and Google Scholar for grey literatures. Data were extracted with structured format prepared using Microsoft Excel and exported to Stata/MP 16.0 software for analyses. The test was used to check the heterogeneity between primary studies with a corresponding 95% confidence interval (CI). Results. A total of 23 primary studies were included in the review showing the pooled prevalence of controlled seizure to be 46% (95% CI: 35, 56). A subgroup analysis of the primary studies showed a considerable variation in magnitude of seizure freedom by study regions, age groups, and seizure-free period. The highest prevalence was found in Addis Ababa 52% (95% CI: 29, 75), pediatric patients 77% (95% CI: 71, 83), and a seizure-free period of less than six months 58% (95% CI: 32, 83). On the other hand, the lowest prevalence of controlled seizure was found in Tigray 27% (95% CI: 11, 65), adult patients 43% (95% CI: 32, 54), and a seizure-free period of six or more 41% (95% CI: 32, 51). Higher frequency of seizure before treatment (2.23, 95% CI: 1.15, 3.31) and medication nonadherence (2.7, 95% CI: 1.25, 4.15) had statistically significant association with uncontrolled seizure. Conclusion. In this review, the prevalence of controlled seizure was found to be low. This warrants that clinicians should give more focus to epileptic patients regarding monitoring and evaluation of treatment outcome of epilepsy and factors that affect seizure control in routine clinical services. The use of standardized definition of controlled seizure, designing strategies to identify pharmacoresistant epilepsy and its treatment, and increasing medication adherence are recommended in Ethiopia. The review protocol has been registered with PROSPERO registration number CRD42021215302.

中文翻译：

---

埃塞俄比亚接受抗癫痫药物治疗的癫痫患者的治疗结果：系统评价和荟萃分析

背景。低收入和中等收入国家的癫痫患病率和发病率较高。不受控制的癫痫症极有可能导致残疾、污名化、歧视、侵犯人权和过早死亡。埃塞俄比亚控制缉获的现有研究显示出不一致的结果，需要系统审查和荟萃分析。因此，本综述旨在显示在门诊接受抗癫痫药物治疗的癫痫患者中控制性癫痫发作的汇总流行率。方法. 使用 PubMed/Medline、Science Direct、PsycINFO、Hinnarri 数据库和 Google Scholar 对灰色文献进行了系统的文献检索。使用 Microsoft Excel 准备的结构化格式提取数据并导出到 Stata/MP 16.0 软件进行分析。该检验用于检查具有相应 95% 置信区间 (CI) 的初级研究之间的异质性。结果. 该评价共纳入 23 项主要研究，显示控制性癫痫发作的汇总流行率为 46%（95% CI：35, 56）。对主要研究的亚组分析显示，不同研究区域、年龄组和无癫痫发作期在无癫痫发作程度方面存在相当大的差异。亚的斯亚贝巴的患病率最高 52% (95% CI: 29, 75)，儿科患者 77% (95% CI: 71, 83)，以及小于 6 个月的无癫痫发作期 58% (95% CI: 32, 83)。另一方面，Tigray 27% (95% CI: 11, 65)、成人患者 43% (95% CI: 32, 54) 和无癫痫发作期为 6 或41% (95% CI: 32, 51)。治疗前癫痫发作频率较高 (2.23, 95% CI: 1.15, 3.31) 和药物不依从性 (2.7, 95% CI: 1.25, 4.结论。在本次审查中，发现控制性癫痫发作的流行率很低。这保证了临床医生应该在常规临床服务中更加关注癫痫患者对癫痫治疗结果的监测和评估以及影响癫痫发作控制的因素。埃塞俄比亚建议使用控制性癫痫的标准化定义，设计识别药物耐药性癫痫及其治疗的策略，并增加药物依从性。审查方案已注册 PROSPERO 注册号 CRD42021215302。