Maternal tolerance during pregnancy increases the risk of infection with certain intracellular pathogens. Systemic Salmonella enterica serovar Typhimurium (S.Tm) infection during pregnancy in normally resistant 129X1/SvJ mice leads to severe placental infection, as well as fetal and maternal deaths. However, the effect of oral infection with S.Tm in pregnant mice and the roles of infection-induced inflammation and cell death pathways in contributing to susceptibility to infection are unclear.

中文翻译：

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IFN-α受体缺乏增强宿主对小鼠妊娠期间口服肠沙门氏菌鼠伤寒血清型感染的抵抗力

怀孕期间的母体耐受性增加了感染某些细胞内病原体的风险。在正常耐药的 129X1/SvJ 小鼠中，妊娠期间系统性肠沙门氏菌鼠伤寒血清型 ( S.Tm ) 感染会导致严重的胎盘感染以及胎儿和母体死亡。然而，怀孕小鼠口腔感染S.Tm的影响以及感染诱导的炎症和细胞死亡途径在促进感染易感性中的作用尚不清楚。