Follicular epithelial dysplasia (FED) is described as Hashimoto thyroiditis-related atypia and is thought to be a possible precancerous lesion. Dysplasia as an interface between normal state and carcinoma is described in a wide range of diseases and carcinogenesis chains. On the other hand, inflammation-related atypia and cancerogenesis is also widely studied. In this study, we retrospectively analyzed 91 specimens of thyroid gland surgical resections with FED during a 10-year-period at the university hospital pathology department. The study population consisted of 68 females and 15 males aged between 22 and 86 years. The preoperative cytology diagnoses had mainly been in the indeterminate categories with prevailing AUS/FLUS results in the FED-only group (p = 0.005) and suspicious for malignancy and malignant in the group with FED plus adjacent malignancy. The decision for surgery was malignancy related in 48.2% of the cases. The lesions were sized 0.1–3.5 mm and multifocal in 45.1% of the cases. Immunohistochemically, the atypical cells were cyclin D1-positive in 67.5%, galectin-3 in 72.7%, CK19 in 85.7%, and HBME-1 in 87.0% of cases. In conclusion, FED is suggested to be a pathogenetic link between inflammation-related atypia and papillary carcinoma and thus a premalignant precursor of papillary carcinoma in HT as 36.1% of the specimens contained also papillary carcinoma in the present study. Both histopathological nuclear features and the immunoprofile of FED are widely shared with that of papillary carcinoma.

滤泡上皮发育不良（FED）被描述为桥本甲状腺炎相关的非典型性，被认为是一种可能的癌前病变。作为正常状态和癌症之间的界面的不典型增生在广泛的疾病和致癌链中被描述。另一方面，炎症相关的非典型性和癌变也被广泛研究。在这项研究中，我们回顾性分析了大学医院病理科 10 年间 FED 甲状腺手术切除的 91 例标本。研究人群包括 68 名女性和 15 名男性，年龄在 22 至 86 岁之间。术前细胞学诊断主要属于不确定类别，在仅 FED 组中占主导地位的 AUS/FLUS 结果 (p = 0. 005) 并在 FED 加邻近恶性肿瘤组中怀疑恶性和恶性。在 48.2% 的病例中，手术决定与恶性肿瘤有关。在 45.1% 的病例中，病变大小为 0.1-3.5 mm，多灶性。免疫组化显示，67.5%的非典型细胞为cyclin D1阳性，72.7%为galectin-3，85.7%为CK19，87.0%为HBME-1。总之，FED 被认为是炎症相关非典型性和乳头状癌之间的致病联系，因此是 HT 中乳头状癌的癌前前兆，因为在本研究中 36.1% 的标本也含有乳头状癌。FED 的组织病理学核特征和免疫特征与乳头状癌广泛共享。在 45.1% 的病例中，病变大小为 0.1-3.5 mm，多灶性。免疫组化显示，67.5%的非典型细胞为cyclin D1阳性，72.7%为galectin-3，85.7%为CK19，87.0%为HBME-1。总之，FED 被认为是炎症相关非典型性和乳头状癌之间的致病联系，因此是 HT 中乳头状癌的癌前前兆，因为在本研究中 36.1% 的标本也含有乳头状癌。FED 的组织病理学核特征和免疫特征与乳头状癌广泛共享。在 45.1% 的病例中，病变大小为 0.1-3.5 mm，多灶性。免疫组化显示，67.5%的非典型细胞为cyclin D1阳性，72.7%为galectin-3，85.7%为CK19，87.0%为HBME-1。总之，FED 被认为是炎症相关非典型性和乳头状癌之间的致病联系，因此是 HT 中乳头状癌的癌前前兆，因为在本研究中 36.1% 的标本也含有乳头状癌。FED 的组织病理学核特征和免疫特征与乳头状癌广泛共享。FED 被认为是炎症相关非典型性和乳头状癌之间的致病联系，因此是 HT 中乳头状癌的癌前前兆，因为在本研究中 36.1% 的标本也含有乳头状癌。FED 的组织病理学核特征和免疫特征与乳头状癌广泛共享。FED 被认为是炎症相关非典型性和乳头状癌之间的致病联系，因此是 HT 中乳头状癌的癌前前兆，因为在本研究中 36.1% 的标本也含有乳头状癌。FED 的组织病理学核特征和免疫特征与乳头状癌广泛共享。