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Influence of daily aspirin therapy on ACE2 expression and function—implications for SARS-CoV-2 and patients with aspirin-exacerbated respiratory disease
Clinical & Experimental Allergy ( IF 6.1 ) Pub Date : 2021-05-13 , DOI: 10.1111/cea.13898
Kathleen M Buchheit 1 , Jonathan J Hacker 2 , Deborah H Gakpo 2 , Jyotsna Mullur 2 , Aaqib Sohail 1 , Tanya M Laidlaw 1
Affiliation  

Key Messages

  • Daily aspirin does not change nasal expression of ACE2 or TMPRSS2 or alter levels of angiotensin-derived peptides in patients with AERD or aspirin-tolerant asthma, suggesting that its use is unlikely to increase risk of severe SARS-CoV-2 infection.
  • Patients with AERD or aspirin-tolerant asthma do not have differences in plasma levels of angiotensin-derived peptides compared with non-asthmatic controls.



中文翻译:

每日阿司匹林治疗对 ACE2 表达和功能的影响——对 SARS-CoV-2 和阿司匹林加重呼吸系统疾病患者的影响

关键信息

  • 每日服用阿司匹林不会改变 ACE2 或 TMPRSS2 的鼻腔表达或改变 AERD 或阿司匹林耐受性哮喘患者的血管紧张素衍生肽的水平,这表明其使用不太可能增加严重 SARS-CoV-2 感染的风险。
  • 与非哮喘对照者相比,AERD 或阿司匹林耐受性哮喘患者的血管紧张素衍生肽的血浆水平没有差异。

更新日期:2021-06-28
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