Flavonoids as the largest group of natural phytochemical compounds have received significant attention, as demonstrated by clinical trials, due to their chemotherapeutic and/or pharmacological effects against non-small-cell lung cancer (NSCLC) and asthma. Scutellaria baicalensis (S. baicalensis), known as one of the most popular medicinal plants and used in several countries, contains natural active flavone constituents, with the major compounds of the roots being baicalein, baicalin, wogonin, wogonoside and oroxylin A. S. baicalensis and their compounds are proven to have inhibitory effects on NSCLC cells when used at different concentrations. However, the exact mechanisms by which these compounds exert their therapeutic effects against asthma remain unexplored. Indeed, the mechanisms by which S.baicalensis and its flavone compounds exert a protective effect against nicotine-induced NSCLC and asthma are not yet fully understood. Therefore, this review explores the mechanisms involved in the therapeutic potential of flavone-rich extracts from S. baicalensis in nicotine-induced NSCLC and asthma.

中文翻译：

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黄cut及其天然黄酮类化合物作为潜在药物治疗尼古丁诱发的非小细胞肺癌和哮喘

临床试验证明，由于类黄酮对非小细胞肺癌（NSCLC）和哮喘具有化学治疗和/或药理作用，因此类黄酮已成为备受关注的药物。黄cut（S. baicalensis ），是最流行的药用植物之一，在一些国家中使用，含有天然的活性黄酮成分，其根的主要化合物是黄ical素，黄ical素，wogonin，wogonoside和oroxylin AS baicalensis，其化合物经证实具有抑制作用当以不同的浓度使用时，对NSCLC细胞的影响。然而，这些化合物对哮喘发挥治疗作用的确切机制尚待探索。的确，尚不完全了解黄杆菌及其黄酮化合物对烟碱诱导的NSCLC和哮喘起保护作用的机制。因此，本次审查探讨涉及从富含黄酮提取物的治疗潜力的机制小号。黄ical 尼古丁引起的非小细胞肺癌和哮喘。