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Frontoparietal theta tACS nonselectively enhances encoding, maintenance, and retrieval stages in visuospatial working memory
Neuroscience Research ( IF 2.9 ) Pub Date : 2021-05-13 , DOI: 10.1016/j.neures.2021.05.005
Prangya Parimita Sahu , Philip Tseng

Neurobiological and cognitive evidence suggests that working memory is processed through three distinctive and well-characterized phases: encoding, maintenance, and retrieval. Several studies have reported that applying theta transcranial alternating current stimulation (tACS) to the right prefrontal and parietal cortices can significantly improve visual working memory performance. However, it remains unclear whether the facilitative effect of tACS on visual working memory is due to a domain-general or stage-specific process. In this study, we combined pre-task right frontoparietal theta tACS (6 Hz, 15 min) with a stage-specific change detection paradigm that provided retro-cues during various stages of working memory. This stage-specific tagging via the use of retro-cues enabled us to probe whether theta tACS would create a nonspecific/additive effect that is equal in magnitude across all cognitive stages or would create a stage-specific effect that is interactive with the retro-cue in a particular stage (e.g., maintenance, retrieval). We observed significant retro-cue and theta tACS effects on visual working memory performance, but no interaction between them. This finding suggests that the aforementioned two factors can facilitate visual working memory processing independently in an additive manner. Furthermore, low-performers benefited more from tACS, and their VWM deficit seemed to have originated from the second half of the memory retention stage, which possibly suggests faster memory decay as the key to poor VWM performance. Together, we conclude that frontoparietal theta tACS likely creates a domain-general boost in visual attention, which in turn benefits overall visual working memory processes that are not specific to the information maintenance or retrieval stages.



中文翻译:

Frontoparietal theta tACS 非选择性地增强视觉空间工作记忆的编码、维持和检索阶段

神经生物学和认知证据表明,工作记忆通过三个独特且特征鲜明的阶段进行处理:编码、维持和检索。几项研究报告称,将 theta 经颅交流电刺激 (tACS) 应用于右前额叶和顶叶皮质可以显着提高视觉工作记忆性能。然而,尚不清楚 tACS 对视觉工作记忆的促进作用是由于域一般过程还是阶段特定过程。在这项研究中,我们将任务前右额顶 theta tACS(6 Hz,15 分钟)与特定于阶段的变化检测范式相结合,该范式在工作记忆的各个阶段提供了追溯线索。这种通过使用回溯线索进行的阶段特定标记使我们能够探索 theta tACS 是否会产生在所有认知阶段均等量级的非特异性/附加效应,或者是否会产生与回溯交互的阶段特定效应。特定阶段的提示(例如,维护、检索)。我们观察到显着的复古提示和 theta tACS 对视觉工作记忆性能的影响,但它们之间没有相互作用。这一发现表明,上述两个因素可以以相加的方式独立地促进视觉工作记忆的处理。此外,低表现者从 tACS 中获益更多,他们的 VWM 不足似乎源于记忆保留阶段的后半部分,这可能表明更快的记忆衰退是 VWM 表现不佳的关键。一起,

更新日期:2021-05-13
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