当前位置: X-MOL 学术Neoplasia › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Understanding the roles of N6-methyladenosine writers, readers and erasers in breast cancer
Neoplasia ( IF 4.8 ) Pub Date : 2021-05-14 , DOI: 10.1016/j.neo.2021.04.002
Runping Fang 1 , Lihong Ye 1 , Hui Shi 2
Affiliation  

Breast cancer is believed to be driven by epigenetic regulation of genes implicated in cell proliferation, survival, and differentiation. Recently, aberrant N6-methyladenosine (m6A) decorations turned up as crucial epigenetic regulator for malignant breast cancer, which may serve as new targets for breast cancer treatment. Here we briefly outline the functions of m6A and its regulatory proteins, including m6A “writers,” “readers,” and “erasers” on RNA life fate, recapitulate the latest breakthroughs in understanding m6A modification and its regulatory proteins, and the underlying molecular mechanisms that contribute to the carcinogenesis and the progression of breast cancer, so as to provide potential epigenetic targets for diagnosis, treatment and prognosis in breast cancer.



中文翻译:

了解 N6-甲基腺苷写入器、读取器和橡皮擦在乳腺癌中的作用

乳腺癌被认为是由与细胞增殖、存活和分化相关的基因的表观遗传调控驱动的。最近,异常的N 6 -甲基腺苷 (m 6 A) 修饰成为恶性乳腺癌的关键表观遗传调节因子,这可能成为乳腺癌治疗的新靶点。在这里,我们简要概述了 m 6 A 及其调节蛋白的功能,包括 m 6 A “写者”、“阅读者”和“擦除者”对 RNA 生命命运的影响,概括了理解 m 6的最新突破修饰及其调控蛋白,以及有助于乳腺癌发生和进展的潜在分子机制,为乳腺癌的诊断、治疗和预后提供潜在的表观遗传靶点。

更新日期:2021-05-14
down
wechat
bug