Energy absorption or dissipation ability has been widely developed in tough hydrogels and 3D nano-structured sponges for a variety of applications. However, fully recoverable energy dissipation and fatigue resistance under large deformation is still challenging yet highly desirable. Polymer network with homogeneous chemical crosslinking structures is an efficient way to construct hydrogels with high resilience and fatigue resistance. Unfortunately, such polymer network usually has poor energy dissipation capability. In this paper, we propose a new approach to build the ability of fully recoverable energy dissipation into covalent-crosslink polymer network by integrating soft and hard chains in a uniform crosslinking network and present the one-pot synthesis method for constructing corresponding polymer sponges by low-temperature phase-separation photopolymerization. The application of such polymer sponges as a tissue engineering scaffold, fabricated by using cyclic acetal units and PEG based monomers in particular is demonstrated. For the first time, we show the feasibility of building a synthetic scaffold with the characteristics of high porosity, super compressibility and resilience, fast recovery, completely recoverable energy dissipation, high fatigue resistance, biodegradability and biocompatibility. Such a scaffold is promising in tissue engineering especially in load-bearing applications.

在坚韧的水凝胶和3D纳米结构的海绵中，能量吸收或耗散能力得到了广泛的发展，可用于各种应用。然而，在大变形下完全可恢复的能量耗散和抗疲劳性仍然是挑战性的，但是非常需要。具有均质化学交联结构的聚合物网络是构建具有高回弹性和耐疲劳性的水凝胶的有效方法。不幸的是，这种聚合物网络通常具有较差的能量耗散能力。在本文中，我们提出了一种通过将软链和硬链整合到均匀的交联网络中来将可完全恢复的能量耗散能力构建到共价交联聚合物网络中的新方法，并提出了一种通过一锅法合成低温相的方式来制造相应的聚合物海绵的方法。分离光聚合。展示了这种聚合物海绵作为组织工程支架的应用，特别是通过使用环状缩醛单元和PEG基单体制造的海绵。我们首次展示了构建具有高孔隙率，超压缩性和回弹力，快速恢复，完全可恢复的能量耗散，高抗疲劳性，生物降解性和生物相容性特征的合成支架的可行性。