The area of the subventricular zone (SVZ) in the adult brain exhibits the highest number of proliferative cells, which, together with the olfactory bulb (OB), maintains constant brain plasticity through the generation, migration and integration of newly born neurons. Despite Tau and its malfunction is increasingly related to deficits of adult hippocampal neurogenesis and brain plasticity under pathological conditions [e.g. in Alzheimer's disease (AD)], it remains unknown whether Tau plays a role in the neurogenic process of the SVZ and OB system under conditions of chronic stress, a well-known sculptor of brain and risk factor for AD.

中文翻译：

---

脑室下区嗅球系统中的成人神经源性过程受长期压力下的 Tau 蛋白调节

成人大脑中脑室下区 (SVZ) 区域的增殖细胞数量最多，它与嗅球 (OB) 一起通过新生神经元的生成、迁移和整合来维持恒定的大脑可塑性。尽管 Tau 及其功能障碍越来越多地与病理条件下成人海马神经发生和大脑可塑性的缺陷相关 [例如阿尔茨海默病 (AD)]，但在条件下 Tau 是否在 SVZ 和 OB 系统的神经发生过程中发挥作用仍然未知慢性压力，著名的大脑雕塑家和 AD 的危险因素。