Cryptococcosis is a fungal infection that is rarely reported in patients without human immunodeficiency virus (HIV) infection, especially when the central nervous system (CNS) or pulmonary system is not involved. We report a case of isolated colonic cryptococcosis without disseminated disease in a 64-year-old immunocompetent woman without HIV infection who presented with chronic diarrhea and no episodes of fever or weight loss. The diagnosis was based on histopathology examination. Furthermore, we performed a literature review showing that few reports have been published so far and in the case of colonic cryptococcal infection, the prognosis is favorable among HIV-uninfected patients.

隐球菌病是一种真菌感染，在未感染人类免疫缺陷病毒 (HIV) 的患者中很少报告，尤其是在不累及中枢神经系统 (CNS) 或肺系统时。我们报告了一名 64 岁免疫功能正常且未感染 HIV 的女性患有孤立性结肠隐球菌病而无播散性疾病，她表现为慢性腹泻，无发热或体重减轻发作。诊断基于组织病理学检查。此外，我们进行的文献回顾表明，迄今为止发表的报告很少，在结肠隐球菌感染的情况下，未感染 HIV 的患者预后良好。