ABSTRACT

Introduction:

Titanium (Ti) and their alloys are used as main implant materials in orthopedics and dentistry for decades having superior mechanical properties, chemical stability and biocompatibility. Their rejections due lack of biointegration and bacterial infection are concerning with considerable healthcare costs and impacts on patients. To address these limitations, conventional Ti implants need improvements where the use of surface nanoengineering approaches and the development of a new generation of implants are recognized as promising strategies.

Areas covered:

This review presents an overview of recent progress on the application of surface engineering methods to advance Ti implants enable to address their key limitations. Several promising surface engineering strategies are presented and critically discussed to generate advanced surface properties and nano-topographies (tubular, porous, pillars) able not only to improve their biointegration, antibacterial performances, but also to provide multiple functions such as drug delivery, therapy, sensing, communication and health monitoring underpinning the development of new generation and smart medical implants.

Expert opinion:

Recent advances in cell biology, materials science, nanotechnology and additive manufacturing has progressively influencing improvements of conventional Ti implants toward the development of the next generation of implants with improved performances and multifunctionality. Current research and development are in early stage, but progressing with promising results and examples of moving into in-vivo studies an translation into real applications.

摘要

简介：

几十年来，钛 (Ti) 及其合金被用作骨科和牙科的主要植入材料，具有优异的机械性能、化学稳定性和生物相容性。他们由于缺乏生物整合和细菌感染而被拒绝，这涉及相当大的医疗保健费用和对患者的影响。为了解决这些限制，传统的钛植入物需要改进，其中表面纳米工程方法的使用和新一代植入物的开发被认为是有前途的策略。

涵盖领域：

本综述概述了应用表面工程方法来推进 Ti 植入物的最新进展，以解决其关键局限性。提出并批判性地讨论了几种有前景的表面工程策略，以产生先进的表面特性和纳米形貌（管状、多孔、柱状），不仅能够改善它们的生物整合、抗菌性能，而且还提供多种功能，例如药物递送、治疗、传感、通信和健康监测是新一代智能医疗植入物开发的基础。

专家意见：

细胞生物学、材料科学、纳米技术和增材制造的最新进展逐渐影响了传统钛植入物的改进，以开发具有改进性能和多功能性的下一代植入物。当前的研究和开发处于早期阶段，但正在取得有希望的结果和进入体内研究的例子，并将其转化为实际应用。