People with type 2 diabetes mellitus (DM) are at increased risk of cardiovascular disease (CVD). Cardiovascular autonomic neuropathy (CAN) is an underdiagnosed risk factor for CVD, which is prevalent among people with 2DM and can lead to CVD and CVD-related mortality. Little is known about the risk factors associated with CAN in type 2DM. Thus, the study was aimed to assess CAN using five cardiovascular autonomic reflex tests (represented by Ewing’s score) and explore the factors associated with CAN in people with type 2DM. The studied factors include traditional and serological CVD risk factors obtained from a fasting blood sample and cardiorespiratory fitness (CRF) obtained via attainment of the highest peak of volumes of O2 (VO2Peak). Univariate analysis revealed a significant positive correlation between resting systolic blood pressure (SBP) and Ewing’s score (r=0.47, p=.02) and an inverse correlation between VO2Peak and Ewing’s score (r=−0.64, p=.001). Multivariate linear regression revealed that a significant model that included resting SBP and VO2Peak explained 93.8% of Ewing’s score variance. CAN was associated with two CVD parameters, including resting SBP and CRF, which may indicate the importance of controlling these two factors to prevent or reduce CAN in people with type 2DM.

中文翻译：

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2型糖尿病患者的心血管自主神经病变；心血管自主反射试验研究​​其与经典心血管危险因素的关联：一项横断面研究

患有2型糖尿病（DM）的人患心血管疾病（CVD）的风险增加。心血管自主神经病（CAN）是CVD的一个未被充分诊断的危险因素，在2DM人群中普遍存在，并可能导致CVD和与CVD相关的死亡率。关于2DM型与CAN相关的危险因素知之甚少。因此，该研究旨在使用五种心血管自主反射测试（由Ewing评分代表）评估CAN，并探讨2DM型患者中与CAN相关的因素。研究的因素包括从空腹血样获得的传统和血清CVD危险因素以及通过达到最高O2体积峰值（VO2Peak）获得的心肺适应性（CRF）。单因素分析显示静息收缩压（SBP）与Ewing评分之间呈显着正相关（r = 0.47，p = .02），VO2Peak与Ewing评分之间呈负相关（r = -0.64，p = .001）。多元线性回归显示，一个包含静息SBP和VO2Peak的显着模型解释了Ewing得分变异的93.8％。CAN与两个CVD参数相关，包括静止的SBP和CRF，这可能表明控制这两个因素对于2DM型患者预防或减少CAN的重要性。