Neuropathic pain (NP) after spinal cord injury (SCI) is a disabling condition, without an effective treatment. Hyperexcitability of N-methyl-D-aspartate (NMDA) receptors and oxidative stress have been reported to be associated with pain development. Amantadine, an NMDA receptor antagonist, has been proposed as a potential therapy for NP. However, its use has not been tested for NP after SCI.

中文翻译：

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金刚烷胺通过拮抗 NMDA 受体预防大鼠脊髓损伤后超敏反应和降低氧化应激

脊髓损伤 (SCI) 后的神经性疼痛 (NP) 是一种致残状态，没有有效的治疗方法。据报道，N-甲基-D-天冬氨酸 (NMDA) 受体的过度兴奋和氧化应激与疼痛发展有关。金刚烷胺是一种 NMDA 受体拮抗剂，已被提议作为 NP 的潜在疗法。然而，它的使用尚未在 SCI 后针对 NP 进行过测试。