Many kinds of cancer cells are intrinsically sensitive to ferroptosis, and research interest regarding ferroptosis has been sparked by its significant role in many detrimental diseases. Ferroptosis is a novel type of iron-dependent cell death mediated by accumulation of reactive oxygen species and lipid peroxidation. Furthermore, a large number of small agents can induce ferroptosis in numerous kinds of cancer cells, including prostate cancer, pancreatic cancer, breast cancer, lymphomas, and renal cancer. These insights may help discover novel approaches for cancer therapeutic strategies; however, there is considerable uncertainty regarding ferroptosis in head and neck cancer (HNC). So far, no review of the current studies on this topic has been published. Therefore, we here elaborate the mechanisms of ferroptosis and summarize the latest findings regarding its role in HNC according to current literature. The respective findings shed light on the role of ferroptosis in HNC treatment with a number of important implications for future practice in HNC management, as outlined in this review.

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铁死亡的机制及其在头颈部鳞状细胞癌治疗中的应用

许多种类的癌细胞对铁死亡本质上是敏感的，并且由于铁死亡在许多有害疾病中的重要作用引发了对铁死亡的研究兴趣。铁死亡是一种新型的铁依赖性细胞死亡，由活性氧的积累和脂质过氧化介导。此外，大量的小剂可以在多种癌细胞中诱导铁死亡，包括前列腺癌、胰腺癌、乳腺癌、淋巴瘤和肾癌。这些见解可能有助于发现癌症治疗策略的新方法；然而，头颈癌 (HNC) 中的铁死亡存在相当大的不确定性。到目前为止，尚未发表对当前有关该主题的研究的评论。所以，我们在此详细阐述了铁死亡的机制，并根据当前文献总结了有关其在 HNC 中作用的最新发现。如本综述所述，各自的研究结果阐明了铁死亡在 HNC 治疗中的作用，对 HNC 管理的未来实践具有许多重要意义。