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Nanoparticles in enhancing microwave imaging and microwave Hyperthermia effect for liver cancer treatment
Reviews on Advanced Materials Science ( IF 3.6 ) Pub Date : 2021-01-01 , DOI: 10.1515/rams-2021-0014
Walaa Maamoun 1 , Mohamed I. Badawi 2 , Ayman A Aly 3 , Y. Khedr 3
Affiliation  

Hyperthermia therapy is a promising therapy for liver cancer treatment that utilizes external electromagnetic waves to heat the tumor zone to preferentially kill or minimize cancer cells. Nevertheless, it’s a challenge to realize localized heating of the cancer tissue without harming the surrounding healthy tissue. This research proposes to utilize nanoparticles as microwave absorbers to enhance microwave imaging and achieve localized hyperthermia therapy. A realistic 3D abdomen model has been segmented using 3D Slicer segmentation software, and then the obtained segmented CAD model exported to Computer Simulation Technology (CST STUDIO) for applying the Finite Element Modeling (FEM). Next investigating both imaging and treatment capability. Finally, the specific absorption rate (SAR) and temperature distribution were computed without nanoparticles and with different types of nanoparticles such as gold (GNPs) and silver nanoparticles at frequency 915 MHz. By comparing the achived results, it was seen that Silver nanoparticles can make a great enhancement in raising the temperature. However, this result was unsatisfactory but, after adding gold nanoparticles the temperature exceed 42°C, at frequency 915 MHz which is achieving the hyperthermia treatment without harming the nearby healthy tissue, GNPs also can achieve a great enhancement in SAR result

中文翻译:

纳米粒子可增强微波成像和微波热疗对肝癌的治疗作用

热疗疗法是用于肝癌治疗的有前途的疗法,该疗法利用外部电磁波加热肿瘤区以优先杀死或最小化癌细胞。然而,实现癌组织的局部加热而不损害周围健康组织是一个挑战。这项研究提出利用纳米颗粒作为微波吸收剂来增强微波成像并实现局部热疗。使用3D Slicer分割软件对真实的3D腹部模型进行了分割,然后将获得的分割的CAD模型导出到计算机仿真技术(CST STUDIO),以应用有限元建模(FEM)。接下来研究成像和治疗能力。最后,在没有纳米颗粒的情况下,在915 MHz频率下计算了不同类型的纳米颗粒(例如金(GNP)和银纳米颗粒)时,计算了比吸收率(SAR)和温度分布。通过比较所获得的结果,可以看出银纳米颗粒可以大大提高温度。但是,此结果并不令人满意,但是在添加温度超过42°C的金纳米颗粒后,在915 MHz的频率下实现了高温治疗而又不损害附近的健康组织,GNP也可以极大地提高SAR结果
更新日期:2021-01-01
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