Environmental exposure to low cleanliness prevents the occurrence of allergic diseases and increases the richness and diversity of the intestinal microbiota. Antibiotics are widely used in clinical infection therapy but destroy the balance of the gut microbiota. In this study, the effects of cleanliness of the living environment on the gut microbiota are evaluated after administration of antibiotics. The patterns of gut microbiota are compared before and after antibiotic treatment in mice living in a higher standard clean environment with those of mice living in an unclean environment. The results show that dust exposure prevents the reduction in gut microbiota diversity following antibiotic treatment in mice and impaired structural changes in the gut microbiota. Additionally, dust exposure accelerates the recovery of the gut microbiota, regardless of consumption of a high-fat or normal diet. An unsanitary environment can reduce the effects of antibiotics on intestinal microecology in mice. These findings provide insights into approaches for regulating antibiotic-induced symbiosis of the gut microbiota and preventing diseases.

中文翻译：

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土壤暴露加速抗生素治疗小鼠肠道微生物群的恢复

环境暴露于低清洁度可防止过敏性疾病的发生，并增加肠道微生物群的丰富性和多样性。抗生素广泛用于临床感染治疗，但会破坏肠道微生物群的平衡。在这项研究中，在施用抗生素后评估生活环境清洁度对肠道微生物群的影响。比较了生活在更高标准清洁环境中的小鼠与生活在不清洁环境中的小鼠在抗生素治疗前后的肠道微生物群模式。结果表明，粉尘暴露可防止小鼠抗生素治疗后肠道微生物群多样性的减少，并损害肠道微生物群的结构变化。此外，灰尘暴露会加速肠道微生物群的恢复，无论食用高脂肪或正常饮食。不卫生的环境可以降低抗生素对小鼠肠道微生态的影响。这些发现为调节抗生素诱导的肠道微生物群共生和预防疾病的方法提供了见解。