New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch,Natural Products and Bioprospecting

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New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch
Natural Products and Bioprospecting Pub Date : 2021-05-11 , DOI: 10.1007/s13659-021-00309-w
Qing-Yun Lu _{1,

2} , Jia-Hui Zhang _{1,

3} , Ying-Yao Li _{1,

4} , Xue-Xue Pu _{1,

5} , Cui-Shan Zhang _{1,

2} , Shuai Liu _{1,

2} , Jia-Jia Wan _{1,

2} , Ying-Tong Di ₁ , Xiao-Jiang Hao ₁

Affiliation

One new Daphniphyllum alkaloid, daphnioldhanol A (1), together with three known ones, were isolated from the stem part of Daphniphyllum angustifolium Hutch. Their structures were elucidated by spectroscopic methods and comparing with the literature data. Compound 2 is a new natural product, but known by synthesis as a racemate. Compound 1 exhibited week cytotoxic activity against Hela cell line with IC₅₀ of 31.9 μM.