Introduction: Adult obesity is linked with polycystic ovary syndrome (PCOS), but the importance of body size at ages before PCOS is diagnosed is unknown. Objective: To investigate associations between a woman’s own birthweight, childhood body mass index (BMI), height and growth patterns in relation to her risk of PCOS. Methods: We included 65,665 girls from the Copenhagen School Health Records Register, born in the period 1960–1996, with information on birthweight and measured weight and height at the ages of 7–13 years. Overweight was defined using International Obesity Task Force (IOTF) criteria. From the Danish National Patient Register, 606 women aged 15–50 years were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated by Cox regression analysis. Results: Birthweight was not associated with PCOS. At the age of 7–13 years, girls with overweight had a higher risk of developing PCOS than girls without overweight; HR 2.83 (95% CI 2.34–3.42) at age 7 years and 2.99 (95% CI 2.38–3.76) at age 13 years. Furthermore, girls with overweight at both 7 and 13 years had a higher risk of developing PCOS than girls without overweight or overweight at only one age. Height was positively associated with PCOS risk at all ages. Girls who were persistently tall or changed from tall to average height had a higher risk of developing PCOS than girls with average height growth. Conclusion: Overweight and tall stature in childhood are positively associated with PCOS risk, but birthweight is not.
Obes Facts

中文翻译：

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出生体重、儿童体重指数、身高和生长情况以及多囊卵巢综合征的风险

简介：成人肥胖与多囊卵巢综合征 (PCOS) 相关，但在诊断出 PCOS 之前，身体大小的重要性尚不清楚。目的：调查女性自身的出生体重、儿童体重指数 (BMI)、身高和生长模式与其患 PCOS 风险之间的关联。方法：我们纳入了来自哥本哈根学校健康记录登记册的 65,665 名出生于 1960 年至 1996 年的女孩，并提供了 7 至 13 岁的出生体重以及测量的体重和身高信息。超重是使用国际肥胖工作组 (IOTF) 标准定义的。从丹麦国家患者登记册中，确定了 606 名年龄在 15-50 岁之间的女性。风险比 (HR) 和 95% 置信区间 (CI) 由 Cox 回归分析估计。结果：出生体重与 PCOS 无关。在 7-13 岁期间，超重女孩比未超重女孩患 PCOS 的风险更高；7 岁时 HR 2.83 (95% CI 2.34–3.42)，13 岁时 HR 2.99 (95% CI 2.38–3.76)。此外，7 岁和 13 岁超重的女孩患 PCOS 的风险高于未超重或仅在一岁时超重的女孩。在所有年龄段，身高都与 PCOS 风险呈正相关。与平均身高增长的女孩相比，持续高或从高变为平均身高的女孩患 PCOS 的风险更高。结论：儿童期超重和身材高大与 PCOS 风险呈正相关，但出生体重并非如此。
肥胖事实