As an environmental contaminant, Benzo[a]pyrene (B[a]P; BaP) disrupts the antioxidant signaling and thus leads to the induction of oxidative stress and the damage of DNA in the ovary. low-dose atorvastatin (ATV) has antioxidant and anti-apoptotic properties. The present study aimed to survey the effects of prenatal exposure to BaP on ovarian toxicity and also to investigate the protective role of ATV in reducing ovarian toxicity. In this study, rats were divided into seven groups: control, ATV (10 mg/kg), oil, BaP (10 and 20 mg/kg), and ATV + BaP (10 and 20 mg/kg). BaP and ATV were administrated from gestation day 7–16 (GD7 to GD16), orally. 10 weeks after the birth, female offsprings were examined for oxidative stress markers, sex hormones, ovarian and tubular tissue structure, and the apoptosis markers. Data showed that BaP significantly reduced glutathione, increased malondialdehyde level, and disrupted the tissue structure of the ovary. Moreover, estrogen and progesterone levels significantly decreased in the offsprings rats. Also, BaP increased caspase-3 immunoreactivity. Atorvastatin treatment along with BaP in the embryonic period were able to bring the antioxidant status and sex hormones levels relatively close to normal. Besides, histological findings showed that atorvastatin was able to improve ovarian and oviduct abnormalities caused by BaP. Based on the above studies be concluded that atorvastatin in the embryonic during was able to reduce ovarian damage caused by BaP with antioxidant and anti-apoptotic properties.

中文翻译：

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产前苯并[a]芘暴露对卵巢毒性和生殖功能障碍的影响：阿托伐他汀对胚胎期的保护作用

作为环境污染物，苯并 [a] 芘 (B[a]P; BaP) 会破坏抗氧化信号，从而导致氧化应激的诱导和卵巢中 DNA 的损伤。低剂量阿托伐他汀 (ATV) 具有抗氧化和抗凋亡特性。本研究旨在调查产前暴露于 BaP 对卵巢毒性的影响，并调查 ATV 在降低卵巢毒性方面的保护作用。在这项研究中，大鼠分为七组：对照、ATV（10 毫克/公斤）、油、BaP（10 和 20 毫克/公斤）和 ATV + BaP（10 和 20 毫克/公斤）。BaP 和 ATV 从妊娠第 7-16 天（GD7 至 GD16）口服给药。出生后 10 周，检查雌性后代的氧化应激标志物、性激素、卵巢和管状组织结构以及细胞凋亡标志物。数据显示，BaP 显着减少谷胱甘肽，增加丙二醛水平，并破坏卵巢的组织结构。此外，后代大鼠的雌激素和孕激素水平显着降低。此外，BaP 增加了 caspase-3 的免疫反应性。阿托伐他汀在胚胎期与 BaP 一起治疗能够使抗氧化状态和性激素水平相对接近正常。此外，组织学发现表明，阿托伐他汀能够改善由 BaP 引起的卵巢和输卵管异常。基于以上研究得出的结论是，胚胎期阿托伐他汀具有抗氧化和抗凋亡特性，能够减少BaP引起的卵巢损伤。后代大鼠的雌激素和孕激素水平显着降低。此外，BaP 增加了 caspase-3 的免疫反应性。阿托伐他汀在胚胎期与 BaP 一起治疗能够使抗氧化状态和性激素水平相对接近正常。此外，组织学发现表明，阿托伐他汀能够改善由 BaP 引起的卵巢和输卵管异常。基于以上研究得出的结论是，胚胎期阿托伐他汀具有抗氧化和抗凋亡特性，能够减少BaP引起的卵巢损伤。后代大鼠的雌激素和孕激素水平显着降低。此外，BaP 增加了 caspase-3 的免疫反应性。阿托伐他汀在胚胎期与 BaP 一起治疗能够使抗氧化状态和性激素水平相对接近正常。此外，组织学发现表明，阿托伐他汀能够改善由 BaP 引起的卵巢和输卵管异常。基于以上研究得出的结论是，胚胎期阿托伐他汀具有抗氧化和抗凋亡特性，能够减少BaP引起的卵巢损伤。此外，组织学发现表明，阿托伐他汀能够改善由 BaP 引起的卵巢和输卵管异常。基于以上研究得出的结论是，胚胎期阿托伐他汀具有抗氧化和抗凋亡特性，能够减少BaP引起的卵巢损伤。此外，组织学发现表明，阿托伐他汀能够改善由 BaP 引起的卵巢和输卵管异常。基于以上研究得出的结论是，胚胎期阿托伐他汀具有抗氧化和抗凋亡特性，能够减少BaP引起的卵巢损伤。