Malignant transformation and tumor progression are accompanied by significant perturbations in metabolic programs. As such, cancer cells support high ATP turnover to construct the building blocks needed to fuel neoplastic growth. The coordination of metabolic networks in malignant cells is dependent on the collaboration with cellular signaling pathways. Glycogen synthase kinase 3 (GSK3) lies at the convergence of several signaling axes, including the PI3K/AKT/mTOR, AMPK, and Wnt pathways, which influence cancer initiation, progression and therapeutic responses. Accordingly, GSK3 modulates metabolic processes, including protein and lipid synthesis, glucose and mitochondrial metabolism, as well as autophagy. In this review, we highlight current knowledge of the role of GSK3 in metabolic perturbations in cancer.

恶性转化和肿瘤进展伴随着代谢程序的显着扰动。因此，癌细胞支持高 ATP 周转，以构建促进肿瘤生长所需的构建块。恶性细胞中代谢网络的协调取决于与细胞信号通路的协作。糖原合酶激酶 3 (GSK3) 位于几个信号轴的汇合处，包括 PI3K/AKT/mTOR、AMPK 和 Wnt 通路，它们影响癌症的发生、进展和治疗反应。因此，GSK3 调节代谢过程，包括蛋白质和脂质合成、葡萄糖和线粒体代谢以及自噬。在这篇综述中，我们重点介绍了 GSK3 在癌症代谢紊乱中的作用的最新知识。