Calcium ions (Ca²⁺) and the complex regulatory system governed by Ca²⁺ signaling have been described to be of crucial importance in numerous aspects related to cell life and death decisions, especially in recent years. The growing attention given to this second messenger is justified by the pleiotropic nature of Ca²⁺-binding proteins and transporters and their consequent involvement in cell fate decisions. A growing number of works highlight that deregulation of Ca²⁺ signaling and homoeostasis is often deleterious and drives pathological conditions; in particular, a disruption of the main Ca²⁺-mediated death mechanisms may lead to uncontrolled cell growth that results in cancer. In this work, we review the latest useful evidence to better understand the complex network of pathways by which Ca²⁺ regulates cell life and death decisions.

钙离子 (Ca ²⁺ ) 和由 Ca ²⁺信号控制的复杂调节系统已被描述为在与细胞生死决定相关的许多方面至关重要，尤其是近年来。Ca ²⁺结合蛋白和转运蛋白的多效性以及它们随后参与细胞命运决定，证明了对第二信使的日益关注是合理的。越来越多的作品强调，Ca ²⁺信号传导和稳态的失调通常是有害的，并会导致病理状况；特别是，主要 Ca ²⁺的中断介导的死亡机制可能导致不受控制的细胞生长，从而导致癌症。在这项工作中，我们回顾了最新的有用证据，以更好地了解 Ca ²⁺调节细胞生死决定的复杂通路网络。