Background: Prolactin (PRL) hormone circulates in the blood in three forms, mono-prolactin which constitutes 85 % of prolactin in healthy and hyperprolactinemia conditions, a dimeric prolactin (big PRL) and polymeric PRL (big-big prolactin or Macroprolactin). Macroprolactin in normal conditions is not exceeding 2% of the total serum prolactin and had no biological activity. In some cases, of hyperprolactinemia the dominant form becomes MaPRL and exceeding the 2% percentage of total leading to misdiagnosis of hyperprolactinemia and un-necessary radiological investigations. The aim of this study is to detect the prevalence of MaPRL in Psychiatric patients with hyperprolactinemia due to anti-psychotic medications at Al Masarra hospital. Material and methods: The study was conducted on 190 samples from patients with high prolactin in Al Masarra Hospital either inpatients or out-patient clinics either male or non-lactating not pregnant female. The measurement of Prolactin level was measured by the automated analyser COBAS e411, Roche Diagnostic. Macroprolactin was precipitated by using Polyethylene glycol (PEG). Results: Prevalence of Macroprolactin was 10.5 % of hyperprolactinemic patients receiving antipsychotics. There was a statistically significant difference in gender between the symptomatic and asymptomatic group. There was no significant difference in medications used between the symptomatic and asymptomatic group and there was a statistically significant difference in total Prolactin & Macroprolactin between males and females. Conclusions: Investigation for Macroprolactin should be done in every hyperprolactinemia patient who is receiving antipsychotics more especially the asymptomatic cases to avoid unnecessary radiological imaging and treatment.

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大催乳素在接受抗精神病药治疗的高泌乳素血症患者中的患病率

背景：催乳素（PRL）激素以三种形式在血液中循环，在健康和高泌乳素血症的情况下，单催乳素占催乳素的85％，二聚催乳素（大PRL）和聚合PRL（大催乳素或大催乳素）。在正常情况下，大泌乳素不超过总血清泌乳素的2％，并且没有生物学活性。在某些情况下，高催乳素血症的显性形式为MaPRL，超过总比例的2％，会导致高催乳素血症的误诊和不必要的放射学检查。这项研究的目的是检测在Al Masarra医院使用抗精神病药物治疗的高催乳素血症精神病患者中MaPRL的患病率。材料与方法：该研究是在Al Masarra医院住院或门诊的男性或非哺乳期未怀孕女性的190位高催乳素样本中进行的。催乳素水平的测量是通过自动分析仪COBAS e411（罗氏诊断公司（Roche Diagnostic））进行的。通过使用聚乙二醇（PEG）沉淀大催乳素。结果：接受抗精神病药治疗的高泌乳素血症患者中大泌乳素的患病率为10.5％。有症状组和无症状组之间的性别差异有统计学意义。有症状组和无症状组之间使用的药物没有显着差异，男性和女性之间总催乳素和大泌乳素的统计学差异也有统计学意义。结论：