Abstract

Purpose

To date, only a few studies have examined long-term health risks of exposures in the uranium processing industry and reported contradictory results, necessitating further research in this area. This is the first description of a cohort of ∼65,000 uranium processing workers (20.6% women) of the Siberian Group of Chemical Enterprises (SGCE) in Seversk, Russia, first employed during 1950-2010.

Methods

SGCE is one of the largest and oldest uranium processing complexes in the world. SGCE workers at the Radiochemical, Plutonium, Sublimate and Enrichment plants were exposed to a combination of internal and external radiation, while workers at the Support Facility were primarily exposed to non-radiation factors.

Results

Mean cumulative gamma-ray dose based on individual external dosimetry was 28.3 millisievert. About 4,000 workers have individual biophysical survey data that could be used for estimation of organ doses from uranium. SGCE workers were followed up for mortality and cancer incidence during 1950-2013 (vital status known for 80.8% of workers). The SGCE computerized database contains information on the results of regular medical examinations, and on smoking, alcohol and other individual characteristics.

Conclusions

The SGCE cohort is uniquely suited to examine long-term health risks of exposures to gamma-radiation and long-lived radionuclides in uranium processing workers.

中文翻译：

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俄罗斯 Seversk 西伯利亚化工企业集团工人队列职业暴露和医疗随访的描述特征

摘要

目的

迄今为止，只有少数研究检查了铀加工业暴露的长期健康风险，并报告了相互矛盾的结果，需要在该领域进一步研究。这是对位于俄罗斯 Seversk 的西伯利亚化学企业集团 (SGCE) 的约 65,000 名铀加工工人（20.6% 为女性）组成的队列的首次描述，该队列于 1950 年至 2010 年期间首次受雇。

方法

SGCE 是世界上最大和最古老的铀加工综合体之一。放射化学、钚、升华和浓缩工厂的 SGCE 工人暴露于内部和外部辐射的组合，而支持设施的工人主要暴露于非辐射因素。

结果

基于个体外部剂量测定的平均累积伽马射线剂量为 28.3 毫西弗。大约 4,000 名工人拥有可用于估算来自铀的器官剂量的个人生物物理调查数据。对 SGCE 工人在 1950-2013 年期间的死亡率和癌症发病率进行了随访（80.8% 的工人已知生命状态）。SGCE 计算机化数据库包含有关定期体检结果以及吸烟、饮酒和其他个人特征的信息。

结论

SGCE 队列特别适合检查铀加工工人暴露于伽马辐射和长寿命放射性核素的长期健康风险。