ABSTRACT

Objective

This study addresses the issue of drawing valid conclusions about the assessment of executive functioning (EF) in long-term survivors of pediatric posterior fossa tumors (PPFT).

Method

All 44 patients (females = 18, mean age = 11 years) were treated consecutively at our department for PPFTs (medulloblastomas, ependymomas, low-grade-gliomas). Four years after diagnosis, their EF was investigated, considering age at diagnosis and treatment type. The validity, sensitivity, and specificity of different EF measures (TMT-B, Number Repetition, WCST, BRIEF) were compared and Strengths-and-Difficulties-Questionnaire was incorporated as a potential screening for EF issues.

Results

EF impairments were found, especially in patients with chemo-/radiotherapy. Caregiver-ratings and performance-based-EF-tests identified different patients as below average. Sensitivity was highest in TMT-B. Strengths-and-Difficulties-Questionnaire was not an adequate screening for EF.

Conclusion

It is essential to assess patients with PPFT with performance-based-tests as well as caregiver-questionnaires, since EF impairments are not always visible at the behavioral level but may still influence everyday life.

中文翻译：

---

后颅窝肿瘤儿科患者执行功能的评估：将基于护理人员的评分和基于绩效的测试相结合的建议

摘要

客观的

本研究解决了对儿童后颅窝肿瘤 (PPFT) 长期幸存者执行功能 (EF) 评估得出有效结论的问题。

方法

所有 44 名患者（女性 = 18，平均年龄 = 11 岁）在我科连续接受了 PPFT（髓母细胞瘤、室管膜瘤、低级别胶质瘤）治疗。诊断四年后，考虑到诊断和治疗类型的年龄，对他们的 EF 进行了调查。比较了不同 EF 测量（TMT-B、数字重复、WCST、BRIEF）的有效性、敏感性和特异性，并结合了优势和困难问卷作为 EF 问题的潜在筛查。

结果

发现了 EF 损伤，尤其是在接受化疗/放疗的患者中。护理人员评级和基于绩效的 EF 测试将不同的患者确定为低于平均水平。TMT-B 的敏感性最高。优势和困难问卷不是对 EF 的充分筛查。

结论

必须通过基于表现的测试和看护者问卷评估 PPFT 患者，因为 EF 损伤并不总是在行为水平上可见，但仍可能影响日常生活。