The heterogeneity in the distribution and morphological features of TAR DNA-binding protein-43 (TDP-43) pathology in the brains of frontotemporal lobar degeneration (FTLD-TDP) patients and their different clinical manifestations suggest that distinct pathological TDP-43 strains could play a role in this heterogeneity between different FTLD-TDP subtypes (A-E). Our aim was to evaluate the existence of distinct TDP-43 strains in the brains of different FTLD-TDP subtypes and characterise their specific seeding properties in vitro and in vivo.

中文翻译：

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来自 FTLD-TDP 亚型的不同脑源性 TDP-43 菌株在体外和体内诱导不同形态的 TDP-43 聚集体和扩散模式

额颞叶变性 (FTLD-TDP) 患者大脑中 TAR DNA 结合蛋白 43 (TDP-43) 病理分布和形态学特征的异质性及其不同的临床表现表明，不同的病理 TDP-43 菌株可能发挥作用不同 FTLD-TDP 亚型 (AE) 之间的这种异质性中的作用。我们的目的是评估不同 FTLD-TDP 亚型大脑中不同 TDP-43 菌株的存在，并表征它们在体外和体内的特定播种特性。