Aging is associated with decreased antigen-specific immunity and increased chronic inflammation. While DNA-sensing pathways might be involved, the molecular factors underlying these age-related aberrancies in immune signaling are unclear. Here, we consider the potential role of aging-induced hypomethylated DNA as a putative stimulant of age-associated inflammation.

中文翻译：

---

年龄相关的低甲基化 DNA 对细胞死亡后免疫信号的影响

衰老与抗原特异性免疫力下降和慢性炎症增加有关。虽然可能涉及 DNA 传感通路，但这些与年龄相关的免疫信号异常背后的分子因素尚不清楚。在这里，我们考虑了衰老诱导的低甲基化 DNA 作为年龄相关炎症的推定兴奋剂的潜在作用。